磁共振成像2026，Vol.17Issue(9)：62-68,7.DOI:10.12015/issn.1674-8034.2026.09.009
基于独立成分分析的帕金森病脑网络功能连接改变研究
Altered intranetwork functional connectivity in Parkinson's disease:An independent component analysis study
摘要
Abstract
Objective:To investigate alterations in intranetwork functional connectivity in Parkinson's disease(PD)based on independent component analysis(ICA).Materials and Methods:In this prospective case-control study,resting-state functional magnetic resonance imaging(fMRI)data from 28 patients with PD and 32 healthy controls(HC)were preprocessed.ICA was performed to identify resting-state functional networks.Differences in intranetwork functional connectivity between the two groups were compared,and correlations between the functional connectivity strength of altered brain regions and Unified Parkinson's Disease Rating Scale Part Ⅲ(UPDRS Ⅲ)scores were analyzed.Results:Compared with HC,patients with PD exhibited significantly decreased functional connectivity within the left paracentral lobule of the somatomotor network(SMN)(t=-5.21,PFWE-corr<0.001),as well as within the right middle frontal gyrus(t=-4.71,PFWE-corr=0.015)and right inferior parietal lobule(t=-4.68,PFWE-corr=0.015)of the right frontoparietal network(RFPN).The functional connectivity strength of the left paracentral lobule was negatively correlated with the UPDRS Part Ⅲ score(r=-0.512,P=0.005,q=0.015),whereas no significant correlations were observed between the UPDRS Part Ⅲ score and the functional connectivity strengths of the right middle frontal gyrus(r=0.049,P=0.805,q=0.805)or the right inferior parietal lobule(r=0.115,P=0.560,q=0.805).Conclusions:Reduced functional connectivity within the SMN was associated with motor symptom severity in patients with PD,whereas the clinical implications of reduced functional connectivity within the RFPN remain to be further elucidated.关键词
帕金森病/脑网络/功能连接/磁共振成像/独立成分分析/相关性分析Key words
Parkinson's disease/brain network/functional connectivity/magnetic resonance imaging/independent component analysis/correlation analysis分类
医药卫生引用本文复制引用
王亚鹏,崔晓峰,赵贝贝,胡涛,林碧霞,梁恒瑞..基于独立成分分析的帕金森病脑网络功能连接改变研究[J].磁共振成像,2026,17(9):62-68,7.基金项目
深圳市宝安区医疗卫生科研项目(编号:2024JD311)Medical and Health Research Project of Bao'an District,Shenzhen(No.2024JD311). （编号:2024JD311）
