磁共振成像2026，Vol.17Issue(9)：69-74,91,7.DOI:10.12015/issn.1674-8034.2026.09.010
卒中后认知障碍脑功能多参数静息态磁共振成像研究
Resting-state functional MRI study of post-stroke cognitive impairment based on multiparametric brain function analysis
摘要
Abstract
Objective:To explore the fractional amplitude of low-frequency fluctuation(fALFF),regional homogeneity(ReHo),and voxel-mirrored homotopic connectivity(VMHC)during the resting state in patients with post-stroke cognitive impairment(PSCI),and to investigate their correlations with clinical indicators and neurocognitive assessment scales.Materials and Methods:A total of 61 patients with PSCI admitted to the Department of Neurology of the First Affiliated Hospital of Xinjiang Medical University from June 2025 to December 2025 were enrolled.In addition,50 community-dwelling healthy controls(HC)without a history of cognitive impairment were recruited.All participants underwent resting-state functional magnetic resonance imaging.A two-sample t-test was performed using the DPABI V8.2 software package to compare resting-state functional differences between the two groups and identify brain regions with significant differences.Using the AAL atlas,the fALFF,ReHo,and VMHC values of these regions were extracted,and correlation analyses were performed between these functional indicators and neurocognitive assessment scales.Results:Compared with the HC group,PSCI group showed decreased fALFF values in left medial superior frontal gyrus,left inferior parietal lobule,and right angular gyrus.Decreased ReHo values were observed in left inferior parietal lobule,left middle frontal gyrus,right superior parietal lobule,and right postcentral gyrus.In addition,decreased VMHC values were found in bilateral postcentral gyri,bilateral middle temporal gyri,and bilateral angular gyri.Correlation analysis revealed that fALFF value of left inferior parietal lobule was negatively correlated with Montreal Cognitive Assessment(MoCA)scores(r=-0.29,P=0.021).No significant correlations were found among fALFF,ReHo,or VMHC values of other brain regions and MoCA scores(P>0.05).Conclusions:This study demonstrated that PSCI patients exhibited alterations in fALFF,ReHo,and VMHC values in specific brain regions compared with healthy individuals.Moreover,fALFF value of left inferior parietal lobule was associated with cognitive performance.These findings provide new insights into potential neural mechanisms underlying functional brain alterations in PSCI patients.关键词
卒中后认知障碍/静息态磁共振成像/低频振幅分数/局部一致性/体素镜像同伦连接Key words
post-stroke cognitive impairment/resting-state functional magnetic resonance imaging/fractional amplitude of low-frequency fluctuation/regional homogeneity/voxel-mirrored homotopic connectivity分类
医药卫生引用本文复制引用
张艺瑶,帕哈提·吐逊江,伊木然·苏比,艾尼卡尔江·艾合麦提,徐蕊,罕迦尔别克·库锟,王云玲..卒中后认知障碍脑功能多参数静息态磁共振成像研究[J].磁共振成像,2026,17(9):69-74,91,7.基金项目
国家卫生健康委能力建设和继续教育中心慢病管理研究课题(编号:GWJJMB202510021008) （编号:GWJJMB202510021008）
国家卫生健康委医药卫生科技发展研究中心脑卒中防治技术研究项目(编号:WKZX2025CZ0209) （编号:WKZX2025CZ0209）
"天山英才"科技创新领军人才项目(编号:2023TSYCLJ0027)Chronic Disease Management Research Project of National Health Commission Capacity Building and Continuing Education Center(No.GWJJMB202510021008) （编号:2023TSYCLJ0027）
the Stroke Prevention and Treatment Technology Research Project of the National Health Commission Science and Technology Development Research Center(No.WKZX2025CZ0209) （No.WKZX2025CZ0209）
the Tianshan Talents Program-Leading Talents in Science and Technology Innovation of Xinjiang Uygur Autonomous Region(No.2023TSYCLJ0027). （No.2023TSYCLJ0027）
