湖南中医杂志2026，Vol.42Issue(8)：34-39,6.DOI:10.16808/j.cnki.issn1003-7705.2026.08.007
归脾养心丸治疗射血分数保留慢性心力衰竭伴贫血30例
Clinical effect of Guipi Yangxin pills in treatment of chronic heart failure with preserved ejection fraction accompanied by anemia:An analysis of 30 cases
摘要
Abstract
Objective:To investigate the clinical value of Guipi Yangxin pills in the treatment of chronic heart failure with preserved ejection fraction(HFpEF)accompanied by anemia.Methods:A total of 60 patients with HFpEF and anemia of Qi-blood deficiency and blood stasis syndrome were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group received conventional Western medicine treatment,while those in the treatment group received Guipi Yangxin pills in addition to the treatment in the control group,and both groups were treated for 4 consecutive weeks.The two groups were observed in terms of traditional Chinese medicine(TCM)syndrome score,6-minute walk distance(6MWD),anemia indicators(red blood cell count[RBC],hemoglobin[Hb],hematocrit[HCT],and serum ferritin[SF]),and N-terminal pro-brain natriuretic peptide(NT-proB-NP)before and after treatment,and clinical outcome,the treatment outcome of New York Heart Association(NYHA)cardiac functional grading were assessed for both groups.Results:There was a significant difference in overall response rate between the treatment group and the control group[86.67％(26/30)vs 66.67％(20/30),P＜0.05].After treatment,both groups had significant changes in TCM syndrome score,6MWD,anemia-related indicators(RBC,Hb,and HCT),and NT-proBNP,with significant differences between the two groups after treatment,and there was a significant difference in the treatment outcome of cardiac functional grading between the two groups after treatment(P＜0.05 or P＜0.01);both groups had a significant change in SF level after treatment(P＜0.05).Conclusion:Guipi Yangxin pills combined with conventional Western medicine treatment can improve the clinical symptoms of patients with HFpEF and anemia of Qi-blood deficiency and blood stasis syndrome and thus holds promise for clinical application.关键词
射血分数保留慢性心力衰竭伴贫血/气血两虚血瘀证/中医药疗法/归脾养心丸/中西医结合疗法Key words
chronic heart failure with preserved ejection fraction accompanied by anemia/Qi-blood deficiency and blood stasis syndrome/traditional Chinese medicine therapy/Guipi Yangxin pills/integrated traditional Chinese and Western medicine therapy分类
医药卫生引用本文复制引用
吴钟琴,李娟..归脾养心丸治疗射血分数保留慢性心力衰竭伴贫血30例[J].湖南中医杂志,2026,42(8):34-39,6.基金项目
黄云名老中医传承工作室[国中医药人教函[2022]75号] （）
湖南中医药大学科研项目(2022XYLH148) （2022XYLH148）
