东华大学学报（英文版）2026，Vol.43Issue(4)：1-12,12.DOI:10.19884/j.1672-5220.202412018
辐射接枝制备PBT生物材料用于增强尿酸吸附和血液相容性
Radiation-Grafted PBT Biomaterials for Enhanced Uric Acid Adsorption and Blood Compatibility
莫耀翔 1李淳 1王斯琦 1薛嘉贺 1沈丽 1王衡东 2陈前进1
作者信息
- 1. 东华大学 化学与化工学院,上海 201620
- 2. 中国科学院上海应用物理研究所,上海 201821
- 折叠
摘要
Abstract
The efficient removal of uric acid from blood via purification is a novel approach for the treatment of gout and hyperuricemia.In this study,a new polybutylene terephthalate(PBT)biomembrane with good uric acid adsorption capacity and desirable blood compatibility was prepared via radiation grafting of N-(4-vinylcarbonyloxyphenyl)acetamide(NVA)and acrylic acid(AA).The chemical structure and surface morphology of the modified membrane were characterized by Fourier transform infrared(FTIR)spectroscopy,X-ray photoelectron spectroscopy(XPS),and scanning electron microscopy(SEM).The wettability of the modified membrane was determined by measuring the water contact angle and water absorption rate.The results indicated that the modified membrane exhibited a maximum uric acid adsorption rate of(6.80±0.20)％with minimal impact on blood cell counts.This study provides a promising strategy for developing safe and efficient biomaterials for the treatment of gout and hyperuricemia.关键词
尿酸吸附/辐射接枝/聚对苯二甲酸丁二酯(PBT)/N-(4-乙烯基甲酰氧基苯基)乙酰胺/血液细胞计数Key words
uric acid adsorption/radiation grafting/polybutylene terephthalate(PBT)/N-(4-vinylcarbonyloxyphenyl)acetamide(NVA)/blood cell count分类
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莫耀翔,李淳,王斯琦,薛嘉贺,沈丽,王衡东,陈前进..辐射接枝制备PBT生物材料用于增强尿酸吸附和血液相容性[J].东华大学学报（英文版）,2026,43(4):1-12,12.
