福建农林大学学报（自然科学版）2026，Vol.55Issue(5)：686-695,10.DOI:10.13323/j.cnki.j.fafu(nat.sci.).202604034
真菌中选择性自噬受体Nbr1的研究进展
Research progress of selective autophagy receptor Nbr1 in fungi
摘要
Abstract
[Background]Autophagy is a highly conserved intracellular degradation and recycling pathway in eukaryotes,among which selective autophagy maintains cellular homeostasis by specifically recognizing substrates via selective autophagy receptor(SAR).Neighbor of BRCA1 gene 1(Nbr1),a typical SAR widely distributed across eukaryotes,exhibits unique structural and functional characteristics compared with the well-studied p62/SQSTM1.In fungi,Nbr1 and its homologs are involved in multiple key biological processes,including pexophagy,vacuolar targeting of cytoplasmic hydrolases,regulation of growth and development,stress responses and virulence control of pathogenic fungi.[Progress]This review summarizes current research progress on fungal Nbr1,focusing on its conserved structural features(ZZ domain,FW domain,LIR/AIM motif,etc),the selective autophagy pathways it mediates(pexophagy and Nbr1-mediated vacuolar targeting pathway),its biological functions and evolutionary dynamics in fungi.[Prospect]Multiple knowledge gaps persist in research on fungal Nbr1.Combined with the adoption of cutting-edge technol-ogies and continuous in-depth exploration,future studies will likely unravel its intricate functions and regulatory mechanisms,there-by enriching the theoretical framework governing selective autophagy in fungi.关键词
真菌/选择性自噬/Nbr1/结构特征/过氧化物酶体自噬/NVT 途径/生物学功能Key words
fungi/selective autophagy/neighbor of BRCA1 gene 1/structure/pexophagy/Nbr1-mediated vacuolar targeting pathway/biological function分类
生物科学引用本文复制引用
刘蔺萱,王爱荣..真菌中选择性自噬受体Nbr1的研究进展[J].福建农林大学学报（自然科学版）,2026,55(5):686-695,10.基金项目
福建农林大学科技创新专项(KFB24113). （KFB24113）
