分子影像学杂志2026，Vol.49Issue(8)：998-1005,8.DOI:10.12122/j.issn.1674-4500.2026.08.03
颞下颌关节紊乱病皮质骨微观结构异常:基于双回波超短时间回波磁共振成像的定量证据
Microstructural abnormalities of cortical bone in temporomandibular joint disorders:Quantitative evidence based on dual-echo ultrashort echo time magnetic resonance imaging
摘要
Abstract
Objective To investigate the feasibility and value of dual-echo ultrashort echo time(Dual-echo UTE)magnetic resonance imaging in quantitatively assessing condylar cortical bone abnormalities in patients with temporomandibular disorders(TMD),and to compare differences in cortical bone parameters among the normal control(NC)group,temporomandibular disorders without osteoarthritis(TMDwoOA)group,and temporomandibular joint osteoarthritis(TMJOA)group.Methods A total of 74 TMD patients(62 TMJOA joints,63 TMDwoOA joints)were recruited from the Department of Radiology,Hainan Hospital of PLA General Hospital from March 2023 to January 2025,alongside 30 healthy volunteers(83 NC joints).All participants were performed with bilateral routine MRI and closed-mouth dual-echo UTE MRI scans of the temporomandibular joints.Following group assignment based on condylar morphology,ImageJ software was employed to analyze UTE images to determine the cortical bone area and porosity index(PI).To validate the measurement accuracy of the dual-echo UTE sequence,CT images from 12 TMD patients and 7 volunteers were included as the gold standard,and intra-group correlation coefficient was used to analyze the consistency of UTE measurements of condylar structural parameters.Results UTE sequences presented strong agreement with CT in condylar bone measurements(P<0.001).Cortical bone area in the TMJOA group was significantly reduced compared to the NC group(122.05 vs 131.06 mm²,P<0.05).The mean PI presented a progressive increase with TMD severity(NC:28.05%vs TMDwoOA:31.00%vs TMJOA:34.00%,P<0.05).Conclusion Dual-echo UTE sequences could enable precise quantification of condylar cortical bone abnormalities in TMD patients.The study confirms that TMJOA progression is accompanied by a reduction in cortical bone area and an increase in porosity,providing a reliable imaging tool for monitoring bone degeneration in clinical diagnosis and efficacy evaluation.关键词
颞下颌关节紊乱病/颞下颌关节骨性关节炎/超短回波时间/皮质骨/孔隙率指数Key words
temporomandibular disorder/temporomandibular joint osteoarthritis/ultrashort echo time/cortical bone/porosity index引用本文复制引用
蒋玉娇,王燕一,陈志晔..颞下颌关节紊乱病皮质骨微观结构异常:基于双回波超短时间回波磁共振成像的定量证据[J].分子影像学杂志,2026,49(8):998-1005,8.基金项目
国家重点研发计划(2023YFF1204104) （2023YFF1204104）
