分子影像学杂志2026，Vol.49Issue(8)：1006-1012,7.DOI:10.12122/j.issn.1674-4500.2026.08.04
血清NOX4水平与原发性高血压患者左室几何构型及功能具有相关性
Serum NOX4 levels are associated with left ventricular geometry and function in patients with primary hypertension
摘要
Abstract
Objective To investigate the correlation between serum nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)levels and left ventricular geometric patterns and functional parameters in patients with primary hypertension(PHT).Methods A total of 338 patients diagnosed with PHT at the First Hospital of Shanxi Medical University from June 2024 to May 2025 were enrolled.Based on left ventricular mass index(LVMI)and relative wall thickness(RWT),patients were categorized into four groups:normal geometry(NG,n=209),concentric remodeling(CR,n=55),eccentric hypertrophy(EH,n=50),and concentric hypertrophy(CH,n=24).Serum NOX4 levels were measured using enzyme-linked immunosorbent assay in all groups.General clinical characteristics,biochemical parameters,and left ventricular structural and functional indices were compared among the four groups.Pearson correlation analysis was performed to evaluate the associations between serum NOX4 levels and left ventricular structural/functional parameters.Multivariate logistic regression was used to identify risk factors for abnormal left ventricular geometry in PHT patients.Results Serum NOX4 levels exhibited a stepwise increase across the severity gradient of left ventricular remodeling,with the highest levels in the CH group,followed by EH,CR,and NG groups,and the CH group showed significantly higher levels than the NG group(P<0.05).Significant differences were observed among the four groups in BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),neck circumference,waist circumference,hip circumference,left ventricular end-diastolic diameter(LVEDd),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),LVMI,RWT,left atrial diameter(LAD),left atrial volume index(LAVI),deceleration time(DT),isovolumic relaxation time(IVRT),early(E)and late(A)transmitral flow velocities,E/A ratio,early diastolic mitral annular velocity(e′),E/e′ ratio,left ventricular ejection fraction(LVEF),left ventricular fractional shortening(LVFS),and global longitudinal strain(GLS)(all P<0.05).Pearson correlation analysis revealed that serum NOX4 levels were positively correlated with IVST(r=0.403,P<0.001),LVPWT(r=0.611,P<0.001),LAD(r=0.207,P<0.001),and E/e′(r=0.636,P<0.001),and negatively correlated with LVEF(r=-0.271,P<0.001),E(r=-0.206,P<0.001),e′(r=-0.800,P<0.001),E/A(r=-0.178,P=0.001),and GLS(r=-0.658,P<0.001).Multivariate logistic regression analysis demonstrated that NOX4 was independently associated with EH(OR=2.437,P=0.038)and CH(OR=4.156,P=0.008).Conclusion Elevated serum NOX4 levels are closely associated with abnormal left ventricular geometry in patients with PHT.The graded changes in NOX4 concentrations suggest that NOX4 may be involved in the pathological process of left ventricular remodeling in this population.关键词
原发性高血压/烟酰胺腺嘌呤二核苷酸氧化酶4/左室几何构型/超声心动图Key words
primary hypertension/nicotinamide adenine dinucleotide phosphate oxidase 4/left ventricular geometry/echocardiography引用本文复制引用
穆怡璇,王健..血清NOX4水平与原发性高血压患者左室几何构型及功能具有相关性[J].分子影像学杂志,2026,49(8):1006-1012,7.基金项目
国家自然科学基金(82371989) （82371989）
山西省归国留学人员科研资助项目(2024-085)Supported by National Natural Science Foundation of China(82371989). （2024-085）
