分子影像学杂志2026，Vol.49Issue(8)：1013-1021,9.DOI:10.12122/j.issn.1674-4500.2026.08.05
左心房周围心外膜脂肪体积和左心房容积是房颤的独立相关因素:基于心脏CT血管成像
Independent associations of left atrial epicardial adipose tissue volume and left atrial volume with atrial fibrillation:based on cardiac CT angiography
摘要
Abstract
Objective To investigate the associations of left atrial(LA)epicardial adipose tissue volume(EATV)and CT attenuation with left atrial volume(LAV)in atrial fibrillation(AF).Methods This retrospective study enrolled 77 patients with AF and 77 patients with sinus rhythm who underwent cardiac CT angiography from January 2022 to June 2025.Total EATV(T-EATV),EAT CT attenuation,LA-EATV,and LA-EAT CT attenuation were measured using Siemens syngo.via.Three-dimensional LA models were reconstructed using 3D Slicer to calculate LAV.Between-group differences were compared,and multivariable logistic regression and Spearman correlation analyses were performed.Results Heart rate and body mass index were significantly higher in the AF group than in the sinus rhythm group(P<0.05).Age,gender,hypertension,diabetes mellitus,and coronary artery disease did not differ significantly between groups(P>0.05).LAV,T-EATV,LA-EATV,T-EAT CT attenuation,LA-EAT CT attenuation,and pericoronary fat CT attenuation values of all three coronary arteries were significantly higher in the AF group(P<0.001).ROC curve analysis showed that LAV had the highest diagnostic performance for AF,with an AUC of 0.849,an optimal cutoff of 117.45 cm³,a sensitivity of 76.6%,and a specificity of 84.4%.LA-EATV(OR=1.337,95%CI:1.051-1.701,P=0.018),LAV(OR=1.045,95%CI:1.018-1.073,P=0.001),LCX pericoronary fat CT attenuation(OR=1.132,95%CI:1.016-1.261,P=0.025),and NT-proBNP(OR=1.004,95%CI:1.001-1.007,P=0.019)were independently associated with AF.T-EATV and T-EAT CT attenuation were not independently associated with AF.LAV was moderately positively correlated with LA-EATV(r=0.392,P<0.001).Conclusion LA-EATV and LAV were independently associated with AF and showed a moderate positive correlation.LA-EATV may provide complementary information to LAV for assessing AF-related left atrial remodeling from the perspective of local fat deposition.关键词
心房颤动/心外膜脂肪组织/左心房容积/心脏CT血管成像Key words
atrial fibrillation/epicardial adipose tissue/left atrial volume/cardiac CT angiography引用本文复制引用
曾子康,徐小红,杨诺言,韩宇阳,刘玉..左心房周围心外膜脂肪体积和左心房容积是房颤的独立相关因素:基于心脏CT血管成像[J].分子影像学杂志,2026,49(8):1013-1021,9.基金项目
安徽省卫生健康科研项目(AHWJ2024BAi30008) （AHWJ2024BAi30008）
