肝胆胰外科杂志2026，Vol.38Issue(9)：650-655,6.DOI:10.11952/j.issn.1007-1954.2026.09.007
SPOCD1、VEGF在胆囊癌组织中的表达及其与胆囊癌患者根治术后预后的关系
Expressions of SPOCD1 and VEGF in gallbladder cancer tissue and their association with the prognosis of gallbladder cancer patients after radical cholecystectomy
摘要
Abstract
Objective To investigate the expressions and significance of SPOC domain-containing protein 1(SPOCD1)and vascular endothelial growth factor(VEGF)in gallbladder cancer and their association with clinicopathological features and prognosis of gallbladder cancer patients.Methods Fifty-nine specimens of gallbladder cancer tissue obtained from surgical resection in the Fifth People's Hospital of Wuxi from January 2017 to December 2023 were collected as the gallbladder cancer group.Chronic cholecystitis tissues from 20 patients who underwent surgical resection during the same period in the same hospital were collected as the control group.The expressions of SPOCD1 and VEGF in these specimens were determined by immunohistochemical staining,and the chi-square test was used to analyze the expression differences between the two groups.The Kaplan-Meier method was used to analyze the SPOCD1 and VEGF expression and survival prognosis of gallbladder cancer patients.A multivariate Cox regression model was conducted to assess the prognotic factors of gallbladder cancer patients.Results Both positive expression rates of SPOCD1 and VEGF protein in gallbladder cancer group were significantly higher than those in control group[66.10%(39/59)vs 15.00%(3/20),χ2=15.665,P<0.05;71.19%(42/59)vs 20.00%(4/20),χ2=16.090,P<0.05].SPOCD1 positive expression in gallbladder cancer tissues was associated with TNM stage(χ2=5.336,P<0.05),vascular invasion(χ2=4.101,P<0.05),and lymph node metastasis(χ2=13.190,P<0.05).VEGF positive expression in gallbladder cancer tissue was associated with vascular invasion(χ2=7.578,P<0.05)and lymph node metastasis(χ2=7.786,P<0.05).There was a significant positive correlation between SPOCD1 expression and VEGF expression(r=0.335,P<0.05).Survival analysis showed that,the median survival time was significantly shorter in gallbladder cancer patients with positive expression of SPOCD1 or VEGF than in those with negative expression[9.0(95%CI 6.4 to 11.6)months vs 32(95%CI 28.1 to 35.9)months,χ2=17.176,P<0.05;9.0(95%CI 6.6 to 11.4)months vs 32.0(95%CI 21.2 to 42.8)months,χ2=16.123,P<0.05].Multivariate Cox regression analysis showed that,positive SPOCD1 expression(HR=2.959,95%CI 1.286 to 6.811,P<0.05),positive VEGF expression(HR=2.796,95%CI 1.232 to 6.346,P<0.05),lymph node metastasis(HR=2.504,95%CI 1.042 to 6.017,P<0.05)and vascular invasion(HR=2.019,95%CI 1.027 to 3.970,P<0.05)were independent risk factors for poor prognosis in gallbladder cancer patients.Conclusion SPOCD1 and VEGF are highly expressed in gallbladder cancer tissues.Positive expression of SPOCD1 and VEGF are independent risk factors for poor postoperative prognosis in gallbladder cancer patients.关键词
胆囊癌/含SPOC结构域蛋白1(SPOCD1)/血管内皮生长因子(VEGF)/根治性切除术/预后Key words
gallbladder cancer/SPOC domain-containing protein 1(SPOCD1)/vascular endothelial growth factor(VEGF)/radical resection/prognosis分类
医药卫生引用本文复制引用
李福利,夏伟,陈杰,吴涛,刘洪,谢伟选..SPOCD1、VEGF在胆囊癌组织中的表达及其与胆囊癌患者根治术后预后的关系[J].肝胆胰外科杂志,2026,38(9):650-655,6.基金项目
安徽医科大学校科研基金项目(2021xkj120). （2021xkj120）
