赣南医科大学学报2026，Vol.46Issue(8)：705-711,7.DOI:10.3969/j.issn.2097-7174.2026.08.003
NHHR与糖尿病血管并发症风险的关联——基于循证医学思考
Risk of NHHR and diabetic vascular complications:evidence-based medicine thinking
摘要
Abstract
Diabetic vascular complications(DVC)are the leading cause of mortality and disability in diabetic patients.Its risk prediction needs new tools that go beyond traditional blood lipid indicators.Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio(NHHR),as a composite indicator that integrates information on atherosclerosis and protective lipoproteins,has demonstrated superiority in assessing the risk of DVC in recent years.This review,based on evidence-based literature,demonstrates that NHHR is closely associated with the risk of DVC,exhibiting superior predictive performance over traditional indicators,and identifies a clinically meaningful risk threshold.Further analysis reveals that the mechanisms by which NHHR participates in the pathogenesis of DVC involve endothelial dysfunction,oxidative stress,and inflammatory activation.Moreover,therapeutic strategies targeting NHHR also show promise for clinical translation.In summary,NHHR holds potential as a novel predictive biomarker and therapeutic target for DVC.However,future prospective studies are warranted to define its optimal cut-off value and establish feasible clinical application pathways.关键词
糖尿病/糖尿病血管病/高密度脂蛋白胆固醇/非高密度脂蛋白胆固醇/非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值Key words
Diabetes mellitus/Diabetic angiopathies/High-density lipoprotein cholesterol/Non-high-density lipoprotein cholesterol/Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio分类
医药卫生引用本文复制引用
刘煜,秦永章..NHHR与糖尿病血管并发症风险的关联——基于循证医学思考[J].赣南医科大学学报,2026,46(8):705-711,7.基金项目
赣州市科技计划项目(2023LNS36720) （2023LNS36720）
