赣南医科大学学报2026，Vol.46Issue(8)：743-749,774,8.DOI:10.3969/j.issn.2097-7174.2026.08.009
脂肪酸代谢对T细胞活化的调控作用研究
Study on the regulatory role of fatty acid metabolism in T cell activation
摘要
Abstract
In recent years,immunometabolism has emerged as a new research field aimed at exploring the interrelationship between metabolism and immunity.Extensive research has shown that to meet the energy demands associated with proliferation,activation and specific functions,T cells reprogram their metabolic patterns during differentiation.For instance,the proliferation and differentiation of effector T cells require the activation of fatty acid synthesis metabolism,while the differentiation and maturation of regulatory T cells and memory T cells primarily rely on fatty acid oxidation metabolism.Fatty acids are not only essential components of cell membranes but also play multiple roles in biological processes.This review summarizes the regulatory roles of two key processes in fatty acid metabolism(fatty acid synthesis and fatty acid oxidation)in T cell proliferation,differentiation,and function,with the aim of providing new targets and strategies for the intervention of clinical autoimmune diseases.关键词
T细胞/免疫代谢/脂肪酸代谢/分化与功能Key words
T cell/Immunometabolism/Fatty acid metabolism/Differentiation and function分类
医药卫生引用本文复制引用
陶悦,邝莹,陈垒..脂肪酸代谢对T细胞活化的调控作用研究[J].赣南医科大学学报,2026,46(8):743-749,774,8.基金项目
国家自然科学基金地区项目(82260803) （82260803）
江西省自然科学基金项目(20252BAC200581) （20252BAC200581）
