赣南医科大学学报2026，Vol.46Issue(8)：750-756,7.DOI:10.3969/j.issn.2097-7174.2026.08.010
病毒蛋白调控肿瘤免疫逃逸的研究进展
Advancements in virus protein-mediated regulation of tumor immune evasion
摘要
Abstract
Virus proteins,synthesized within host cells from viral genetic templates,play pivotal roles in modulating tumor immunity.Immune evasion constitutes a major bottleneck restricting the efficacy of current cancer immunotherapies,and the intricate regulatory functions of viral proteins in tumor immune escape have become a growing research focus.This review highlights the mechanisms by which these proteins orchestrate immune evasion and promote tumor progression,including disruption of innate immune signaling pathways,impairment of antigen presentation systems,induction of T-cell exhaustion,and remodeling of the tumor immune microenvironment.It further summarizes current clinical intervention strategies targeting viral proteins,encompassing vaccines based on viral antigens,immune checkpoint modulation,and novel combination therapies.These approaches have shown preliminary promise in preclinical and early-phase clinical studies.However,it still faces challenges such as microenvironmental heterogeneity,immune tolerance,and the need for optimized combination regimens.Future efforts should be made to integrate comprehensive characterization of the tumor microenvironment,deepen the understanding of viral protein regulatory networks,and develop multi-target combination strategies to facilitate precision immunotherapy.关键词
病毒蛋白/肿瘤免疫/免疫逃逸/肿瘤微环境/免疫治疗Key words
Virus proteins/Tumor immunology/Immune evasion/Tumor microenvironment/Immunotherapy分类
医药卫生引用本文复制引用
曾祥海,刘悦,刘桂玲,黄丹丹..病毒蛋白调控肿瘤免疫逃逸的研究进展[J].赣南医科大学学报,2026,46(8):750-756,7.基金项目
江西省自然科学青年基金项目(20242BAB21043) （20242BAB21043）
