甘肃中医药大学学报2026，Vol.43Issue(4)：47-52,6.DOI:10.16841/j.issn1003-8450.2026.04.08
远隔缺血适应对急性缺血性脑卒中静脉溶栓治疗后D-二聚体、C反应蛋白水平及临床预后的影响
Effects of remote ischemic conditioning on D-dimer,C-reactive protein levels and clinical prognosis after intravenous thrombolysis in acute ischemic stroke
摘要
Abstract
Objective To investigate the effects of remote ischemic conditioning on serum D-dimer(D-D),whole blood C-reactive protein(CRP)levels,and clinical prognosis in patients with acute ischemic stroke after in-travenous thrombolysis.Methods A total of 60 patients with acute ischemic stroke admitted to the Department of Cerebrovascular Diseases of Gansu Provincial Hospital of Traditional Chinese Medicine from August 2023 to August 2025 were selected as study subjects.They were randomly divided into a control group and a treatment group using a random number table,with 30 cases in each group.Both groups received conventional stroke medication and intrave-nous thrombolysis with alteplase.On this basis,the treatment group received continuous remote ischemic conditioning intervention for one week.The National Institutes of Health Stroke Scale(NIHSS)was used to assess the degree of neurological impairment before thrombolysis and at 24 h,7 d,30 d,and 90 d after thrombolysis.The modified Rankin Scale(mRS)was used to assess neurological functional recovery before thrombolysis and at 90 d after thrombolysis.Serum D-D and whole blood CRP levels were measured by enzyme-linked immunosorbent assay(ELISA)before thrombolysis and at 7 d after thrombolysis.Results At 24 h,7 d,30 d,and 90 d after thrombolysis,NIHSS scores in both groups were significantly decreased and showed a decreasing trend over time,with statistically significant differences compared with those before thrombolysis in the same group(P＜0.05).The decrease was more pro-nounced in the treatment group,and the differences were statistically significant compared with the control group at the corresponding time points after thrombolysis(P＜0.05 or P＜0.01).At 90 d after thrombolysis,mRS scores in both groups were significantly decreased,with statistically significant differences compared with those before throm-bolysis in the same group(P＜0.01),and the decrease was more pronounced in the treatment group,with a statisti-cally significant difference compared with the control group(P＜0.05).At 7 d after thrombolysis,serum D-D and whole blood CRP levels in both groups were significantly decreased,with statistically significant differences com-pared with those before thrombolysis in the same group(P＜0.01),and the decrease was more pronounced in the treatment group,with statistically significant differences compared with the control group(P＜0.05 or P＜0.01).Con-clusion Remote ischemic conditioning can effectively improve neurological function and clinical prognosis in pa-tients with acute ischemic stroke after intravenous thrombolysis,and reduce the levels of the inflammatory factor CRP and the fibrinolysis process marker D-D.关键词
急性缺血性脑卒中/远隔缺血适应/静脉溶栓/美国国立卫生研究院卒中量表评分/改良Rankin量表评分/D-二聚体/C反应蛋白Key words
acute ischemic stroke/remote ischemic conditioning/intravenous thrombolysis/National Institutes of Health Stroke Scale(NIHSS)score/modified Rankin Scale(mRS)score/D-dimer(D-D)/C-reactive protein(CRP)分类
医药卫生引用本文复制引用
汪晶,邵亚,曹骅,石沛薷..远隔缺血适应对急性缺血性脑卒中静脉溶栓治疗后D-二聚体、C反应蛋白水平及临床预后的影响[J].甘肃中医药大学学报,2026,43(4):47-52,6.基金项目
甘肃省卫生健康行业科研计划项目(GSWSKY2022-27). （GSWSKY2022-27）
