国际老年医学杂志2026，Vol.47Issue(5)：567-573,7.DOI:10.3969/j.issn.1674-7593.2026.05.003
基于NHANES数据分析老年高血压人群握力与全因死亡和心血管事件死亡的关联
The relationship between grip strength and All-cause mortality and cardiovascular mortality in elderly hypertensive populations
摘要
Abstract
Objective To explore the association between grip strength and all-cause mortality and cardiovascular mortality risks in elderly hypertensive individuals aged 60 years and older,in order to provide scientific evidence for improving the prognosis of elderly hypertension.Methods Data from the National Health and Nutrition Examination Survey(NHANES)were used to extract elderly hypertensive patients with grip strength,and participants were divided into three groups(Q1,Q2,Q3)based on grip strength tertiles.Cox regression analysis was used to explore the relationship between grip strength and all-cause mortality and cardiovascular e-vent mortality in elderly hypertensive patients.Kaplan-Meier survival curves were used to compare the differences in cumulative surviv-al rates during follow-up among patients with varying grip strength levels.Patients were stratified according to thresholds identified by the maximum Youden index in ROC curve analysis,and the association between handgrip strength and mortality was evaluated using multivariable Cox regression.Results A total of 2,228 individuals were included in the study.The median follow-up time was 77 months.During the follow-up period,there were 545 all-cause deaths and 152 cardiovascular disease deaths.Cox proportional hazards regression model revealed that after adjusting for confounding factors,when using the Q1 group as the reference,the risk of all-cause mortality was lower in the Q2 and Q3 groups(P<0.05),and the risk of cardiovascular event mortality was also lower in the Q2 and Q3 groups(P<0.05).Kaplan-Meier survival curve analysis revealed that the cumulative survival rate during follow-up was significant-ly higher in the Q3 group compared to the Q1 and Q2 groups,and the Q2 group had a higher rate than the Q1 group(P<0.001).ROC curves demonstrated that handgrip strength predicted all-cause mortality with AUCs>0.700 in both genders.Multivariable Cox regression confirmed significantly reduced all-cause and cardiovascular mortality risks in the high handgrip strength group when strati-fied by optimal thresholds.Conclusion High grip strength levels are protective factors for all-cause mortality and cardiovascular event mortality in elderly hypertensive populations.关键词
高血压/握力/全因死亡/心血管事件死亡Key words
Hypertension/Grip strength/All-cause mortality/Cardiovascular event mortality引用本文复制引用
魏薇,崔帅,于志超,徐锐..基于NHANES数据分析老年高血压人群握力与全因死亡和心血管事件死亡的关联[J].国际老年医学杂志,2026,47(5):567-573,7.基金项目
新疆维吾尔自治区自然科学基金(2021D01C163) （2021D01C163）
