中国妇幼健康研究2026，Vol.37Issue(9)：1-6,6.DOI:10.3969/j.issn.1673-5293.2026.09.001
孕中期体水分及凝血四项在妊娠期高血压患者中的水平变化及危险因素分析
Analysis of changes in maternal body water and four blood coagulation parameters and risk factors in patients with gestational hypertension during the second trimester pregnancy
摘要
Abstract
Objective To analyze the changes in body water and four blood coagulation parameters in pregnant women with gestational hypertension during the second trimester,and to explore the related risk factors.Methods 90 pregnant women with gestational hypertension admitted to Hefei maternal and child health hospital from March 2021 to March 2024 were selected as the observation group,and 45 healthy pregnant women in the second trimester were selected as the control group.The observation group was divided into mild group(27 cases),moderate group(38 cases),and high group(25 cases)according to the gestational hypertension symptom grading standard.The levels of body water[total body water(TBW),extra cellular water(ECW),intra cellular water(ICW),skeletal muscle mass(SMM),body fat mass(BFM)]and four blood coagulation parameters[D-dimer(D-D),fibrinogen(FIB),prothrombin time(PT),activated partial thromboplastin time(APTT)]of all study subjects were measured.Multivariate Logistic regression analysis was used to explore the independent risk factors affecting gestational hypertension.Results The levels of TBW,ECW,ICW,SMM,BFM,FIB,D-D in the control group,mild group,moderate group and high group successively increased,while the levels of APTT and PT successively decreased,and the differences were statistically significant(F values ranging from 18.190 to 584.240,P<0.05).Compared with the control group,the proportions of older age(≥35 years),pre-pregnancy BMI≥24 kg/m2,and having a history of hypertension in the observation group were higher,and the differences were statistically significant(χ2 values ranging from 14.466 to 24.068,P<0.05).The results of multivariate Logistic regression analysis showed that older age,higher pre-pregnancy BMI,having a history of hypertension,high levels of TBW,ECW,ICW,SMM,BFM,D-D,FIB were risk factors for gestational hypertension(OR values ranging from 1.429 to 2.972,P<0.05),while high levels of PT and APTT were protective factors(OR values were 0.819 and 0.738,respectively,P<0.05).Conclusion The levels of TBW,ECW,ICW,SMM,BFM,FIB,D-D were higher in pregnant women with gestational hypertension,while the levels of APTT and PT were lower.These parameters are closely related to the occurrence of gestational hypertension.关键词
妊娠期高血压/孕中期/母体水分/凝血四项/危险因素Key words
gestational hypertension/second trimester/maternal body water/four blood coagulation parameters/risk factor分类
医药卫生引用本文复制引用
金艳,张静,张军辉..孕中期体水分及凝血四项在妊娠期高血压患者中的水平变化及危险因素分析[J].中国妇幼健康研究,2026,37(9):1-6,6.基金项目
安徽省自然科学基金项目(2308085MC83) （2308085MC83）
