医学分子生物学杂志2026，Vol.23Issue(5)：541-548,8.DOI:10.3870/j.issn.1672-8009.2026.05.008
结直肠癌组织中SATB2、CK20、MUC2表达及其临床意义
Expression of SATB2,CK20 and MUC2 in Colorectal Cancer and Its Clinical Significance
摘要
Abstract
Objective To investigate the clinical significance of the expression of special AT-rich sequence-binding protein 2(SATB2),cytokeratin 20(CK20),and mucin 2(MUC2)in colorectal cancer(CRC)tissues and their value in prognostic evaluation.Methods A total of 330 CRC patients who underwent radical resection at Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine from March 2020 to March 2022 were retrospectively analyzed.After excluding 15 patients lost to follow-up,315 patients were included in the survival analysis.CRC tissues and paired adjacent normal tissues were collected.Immunohistochemistry was used to detect the expression of the three proteins,and patients were grouped accordingly.The relationships between protein expression and clinicopathological features were analyzed.Kaplan-Meier survival analysis and Cox regression models were used to evaluate prognostic factors.Results The positive expression rates of SATB2 and MUC2 in CRC tissues were lower than those in adjacent tissues,while CK20 expression was higher(P<0.05).Patients with tumor diameter<4 cm,TNM stage Ⅰ～Ⅱ,and no lymph node metastasis showed higher positive rates of SATB2 and MUC2 and lower CK20 positivity(all P<0.05).Univariate and multivariate Cox regression analyses indicated that tumor diameter≥4 cm,TNM stage III-IV,lymph node metastasis,and CK20 positivity were risk factors for poor prognosis,whereas SATB2 and MUC2 positivity was protective factors(all P<0.05).Survival analysis showed that patients positive for SATB2 and MUC2 had lower 3-year mor-tality,while those positive for CK20 had higher mortality(P<0.05).Conclusion The down-regulation of SATB2 and MUC2 expression in CRC tissue is closely related to tumor progression,and their positive expression suggests a better prognosis.The positive expression of CK20 may be related to poor prognosis.The expression status of SATB2,CK20 and MUC2 can be used as poten-tial supplementary markers to judge the prognosis risk of CRC patients.关键词
结直肠癌/特异性AT富集结合蛋白2/细胞角蛋白20/黏蛋白2/预后/生存分析Key words
colorectal cancer/SATB2 binding protein/cytokeratin 20/mucin 2/prognosis/survival analysis分类
医药卫生引用本文复制引用
杨易,章诗伟..结直肠癌组织中SATB2、CK20、MUC2表达及其临床意义[J].医学分子生物学杂志,2026,23(5):541-548,8.基金项目
国家中医药管理局监测统计中心深化医改中医药政策研究项目(No.YGZXKT2024293) This work was supported by a grant from the TCM Policy Research Project for Deepening Medical Reform(No.YGZXKT2024293). （No.YGZXKT2024293）
