医学分子生物学杂志2026，Vol.23Issue(5)：549-555,7.DOI:10.3870/j.issn.1672-8009.2026.05.009
中重度斑块型银屑病患者血清白介素-17、抗菌肽LL-37水平与颈动脉粥样硬化的关系
Relationship Between Serum Interleukin-17,Cathelicidin Antimicro-bial Peptide 37 Levels and Carotid Atherosclerosis in Patients with Moderate-to-Severe Plaque Psoriasis
摘要
Abstract
Objective To investigate the relationship between serum interleukin-17(IL-17),cathelicidin antimicrobial peptide LL-37 levels and carotid atherosclerosis in patients with moderate-to-severe plaque psoriasis.Methods A total of 168 patients with moderate-to-severe plaque psoria-sis admitted between June 2023 and December 2024 were selected and serum IL-17 and LL-37 lev-els were measured.According to cartid intima-media thickness(IMT),patients were divided into atherosclerosis group(IMT≥1.5 mm,n=56)and non-atherosclerosis group(IMT<1.5 mm,n=112).Clinical data and serum IL-17 and LL-37 levels were compared between the two groups.We used Pearson correlation analysis to evaluate the association between serum IL-17,LL-37 levels and IMT.Additionally,logistic regression analysis was applied to determine the factors affecting carotid atherosclerosis.Additionally,receiver operating characteristic(ROC)curve analysis was con-ducted to evaluate the diagnostic efficacy of serum biomarkers for carotid atherosclerosis.Results The Psoriasis Area and Severity Index score and levels of low-density lipoprotein cholesterol(LDLC),C-reactive protein,uric acid,IL-17 and LL-37 in serum of the atherosclerosis group were higher than those of the non-atherosclerosis group(P<0.05).Serum IL-17 and LL-37 showed sig-nificant positive correlations with carotid IMT(P<0.05).Elevated IL-17(OR=1.255),elevated LL-37(OR=1.014),and elevated LDLC(OR=13.278)were risk factors for carotid atherosclerosis(P<0.05).The areas under the curve(AUC)of IL-17,LL-37,LDLC for diagnosing carotid athero-sclerosis were 0.861,0.848,0.702,respectively.The AUCs for IL-17 and LL-37 in diagnosing carotid atherosclerosis were higher than those for LDLC(P<0.05),and there was no statistically sig-nificant difference in the AUCs between IL-17 and LL-37(P>0.05).Conclusion Elevated serum IL-17 and LL-37 levels are associated with carotid atherosclerosis in patients with moderate-to-severe plaque psoriasis.The diagnostic efficacy of IL-17 and LL-37 as diagnostic markers for carotid atherosclerosis is superior to that of LDLC.关键词
中重度斑块型银屑病/颈动脉粥样硬化/血清白介素-17/抗菌肽LL-37/危险因素Key words
moderate-to-severe plaque psoriasis/carotid atherosclerosis/serum interleukin-17/LL-37/risk factors分类
医药卫生引用本文复制引用
赵旭明,柴琴琴,李亚维,景晓蕾,刘晓静,杨晓静,孟昭影..中重度斑块型银屑病患者血清白介素-17、抗菌肽LL-37水平与颈动脉粥样硬化的关系[J].医学分子生物学杂志,2026,23(5):549-555,7.基金项目
河北省卫生健康委员会医学科学研究课题计划(No.20260800) This work was supported by a grant from the Medical Research Program of the Hebei Provincial Health Commission(No.20260800). （No.20260800）
