保健医学研究与实践2026，Vol.23Issue(7)：44-51,8.DOI:10.11986/j.issn.1673-873X.2026.07.07
PLT、D-D和PAB水平对肝癌患者病情及预后的预测价值
Predictive value of PLT,D-D,and PAB levels for disease severity and prognosis in patients with liver cancer
摘要
Abstract
Objective To analyze the predictive value of platelet(PLT),D-dimer(D-D),and prealbumin(PAB)levels for disease severity and prognosis in patients with liver cancer,so as to provide a new reference for individualized treatment and prognostic stratification of liver cancer.Methods A total of 120 patients with liver cancer admitted to Xijing 986 Hospital,Air Force Medical University,from January 2023 to January 2025 were selected as study participants.According to TNM stage,they were assigned to a stage Ⅰ-Ⅱ group(n=72)and a stage Ⅲ-Ⅳ group(n=48).According to prognosis at the 6-month follow-up,they were assigned to a poor prognosis group(n=40)and a good prognosis group(n=80).Serum PLT,D-D,and PAB levels were measured after admission.Logistic regression analysis was used to construct a combined prediction model of PLT,D-D,and PAB.Receiver operating characteristic(ROC)curves were used to analyze the predic-tive performance of individual and combined detection of PLT,D-D,and PAB levels for disease progression and prognosis in these patients.Results Serum PLT and D-D levels in the stage Ⅲ-Ⅳ group were higher than those in the stage Ⅰ-Ⅱgroup,while PAB level was lower than that in the stage Ⅰ-Ⅱ group,with statistically significant differences(P<0.05).Serum PLT and D-D levels in the poor prognosis group were higher than those in the good prognosis group,while PAB level was lower than that in the good prognosis group,with statistically significant differences(P<0.05).Logistic regression a-nalysis showed that elevated serum PLT and D-D levels and decreased PAB level were risk factors for disease progression and prognosis in patients with liver cancer(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of combined detection of serum PLT,D-D,and PAB levels for predicting disease progression in patients with liver cancer was 0.866(95％CI:0.792-0.922),which was higher than that of each single indicator(Z=3.753,2.368,3.380;P<0.05).The AUC of combined detection for predicting prognosis was 0.874(95％CI:0.801-0.927),which was higher than that of each single indicator(Z=3.263,2.465,2.895;P<0.05).Conclusion Detection of PLT,D-D,and PAB levels has certain predictive value for disease severity and prognosis in patients with liver cancer,and their combined detection can im-prove predictive performance.Therefore,early monitoring of PLT,D-D,and PAB levels is recommended in clinical practice to facilitate individualized precision treatment and improve patient prognosis.关键词
肝癌/血小板/D-二聚体/前白蛋白/病情/预后/预测价值Key words
Liver cancer/Platelet/D-dimer/Prealbumin/Disease severity/Prognosis/Predictive value分类
医药卫生引用本文复制引用
成晓梅,王钧,武李红,王翠翠,贺静雅,乔亚琴,王进海,荆玉洁..PLT、D-D和PAB水平对肝癌患者病情及预后的预测价值[J].保健医学研究与实践,2026,23(7):44-51,8.基金项目
陕西省重点研发计划项目(2023-YBSF-485). （2023-YBSF-485）
