保健医学研究与实践2026，Vol.23Issue(7)：52-59,8.DOI:10.11986/j.issn.1673-873X.2026.07.08
血清(1,3)-β-D-葡聚糖联合炎性指标对肺部真菌感染早期诊断的临床价值
Clinical value of serum(1,3)-β-D-glucan combined with inflammatory indicators in the early diagnosis of pulmonary fungal infection
摘要
Abstract
Objective To investigate the value of serum(1,3)-β-D-glucan(BDG)combined with routine inflammatory indica-tors in the early differential diagnosis of pulmonary fungal infection,so as to provide a reference for clinical decision-making.Methods A total of 172 hospitalized patients diagnosed with pulmonary infection who attended the First Affiliated Hospital of University of Science and Technology of China from May 2020 to March 2024 were enrolled.According to their clinical diagnosis,deep sputum or bronchoalveolar lavage fluid culture and/or next-generation sequencing results,they were as-signed to a fungal infection group(91 cases)and a non-fungal infection group(81 cases).BDG,C-reactive protein(CRP),procalcitonin(PCT),white blood cell(WBC)count,and neutrophil(NEU)count at admission were compared between the two groups.Receiver operating characteristic(ROC)curves were used to evaluate the diagnostic value of BDG alone and in combination with other inflammatory indicators for pulmonary fungal infection.Results The BDG level in the fungal infec-tion group was significantly higher than that in the non-fungal infection group(P<0.05).Among the related inflammatory indicators,WBC count and NEU count in the fungal infection group were higher than those in the non-fungal infection group,while CRP level was lower than that in the non-fungal infection group,with statistically significant differences(P<0.05).Among the inflammatory indicators,CRP was positively correlated with PCT,WBC count,and NEU count(r=0.450,P<0.001;r=0.251,P=0.016;r=0.232,P=0.027),and WBC count was positively correlated with NEU count(r=0.947,P<0.001).The area under the curve(AUC)of BDG for predicting early pulmonary fungal infection was 0.805(95%CI:0.802-0.808),with a sensitivity of 71.43%and specificity of 93.83%.After BDG combined with CRP and NEU count,the AUC increased to 0.867(95%CI:0.865-0.869),with a sensitivity of 67.05%and specificity of 95.70%.Conclusion BDG has good diagnostic performance for pulmonary fungal infection,and BDG combined with CRP and NEU count can further enhance its clinical diagnostic value.关键词
肺部真菌感染/(1,3)-β-D-葡聚糖/炎症标志物/联合诊断Key words
Pulmonary fungal infection/(1,3)-β-D-glucan/Inflammatory markers/Combined diagnosis分类
医药卫生引用本文复制引用
万昕,刘昊冉,胡月,张海涛,刘榴,金佩佩,杨舒馨影..血清(1,3)-β-D-葡聚糖联合炎性指标对肺部真菌感染早期诊断的临床价值[J].保健医学研究与实践,2026,23(7):52-59,8.基金项目
国家自然科学基金青年项目(82001706) （82001706）
安徽省高等学校科学研究重点项目(2022AH051257) （2022AH051257）
2025年度皮肤病学教育部重点实验室开放基金项目(AYPYS2025-12). （AYPYS2025-12）
