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Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization,misaligned mineral crystals,and altered osteoblast differentiation

Aileen M.Barnes Ghazal Hedjazi Kiersten Campbell Chris Stephan David R.Eyre Ryan K.Dale Peter Fratzl Kenneth M.Kozloff Nadja Fratzl-Zelman Joan C.Marini M.Helen Rajpar Joseph E.Perosky Stéphane Blouin Basma Khoury MaryAnn Weis Theresa Hefferan Alberta Derkyi Gali Guterman-Ram

骨研究（英文版）2026，Vol.14Issue(4)：1099-1116,18.

骨研究（英文版）2026，Vol.14Issue(4)：1099-1116,18.DOI:10.1038/s41413-026-00531-7

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization,misaligned mineral crystals,and altered osteoblast differentiation

Aileen M.Barnes ¹Ghazal Hedjazi ²Kiersten Campbell ³Chris Stephan ⁴David R.Eyre ⁵Ryan K.Dale ³Peter Fratzl ⁶Kenneth M.Kozloff ⁴Nadja Fratzl-Zelman ⁷Joan C.Marini ¹M.Helen Rajpar ¹Joseph E.Perosky ⁴Stéphane Blouin ⁷Basma Khoury ⁴MaryAnn Weis ⁸Theresa Hefferan ⁹Alberta Derkyi ¹⁰Gali Guterman-Ram¹¹

作者信息

1. Section on Heritable Disorders of Bone and Extracellular Matrix,Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA
2. Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling,1st Med.Department Hanusch Hospital,Vienna,Austria
3. Bioinformatics&Scientific Programming Core,Eunice Kennedy Shriver National Institute of Child Health and Human Development,NIH,Bethesda,MD,USA
4. Department of Orthopaedic Surgery,University of Michigan,Ann Arbor,MI,USA
5. Vienna Bone and Growth Center,Vienna,Austria
6. Max Planck Institute of Colloids and Interfaces,Potsdam,Germany
7. Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling,1st Med.Department Hanusch Hospital,Vienna,Austria||Vienna Bone and Growth Center,Vienna,Austria
8. Department of Orthopaedics and Sports Medicine,University of Washington,Seattle,WA,USA
9. Biomaterials and Histomorphometry Core Laboratory,Mayo Clinic,Rochester,MN,USA
10. Office of the Clinical Director,Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA
11. Section on Heritable Disorders of Bone and Extracellular Matrix,Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health,Bethesda,MD,USA||Faculty of Biomedical Engineering,Technion-Israel Institute of Technology,Haifa,Israel
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Aileen M.Barnes,Ghazal Hedjazi,Kiersten Campbell,Chris Stephan,David R.Eyre,Ryan K.Dale,Peter Fratzl,Kenneth M.Kozloff,Nadja Fratzl-Zelman,Joan C.Marini,M.Helen Rajpar,Joseph E.Perosky,Stéphane Blouin,Basma Khoury,MaryAnn Weis,Theresa Hefferan,Alberta Derkyi,Gali Guterman-Ram..Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization,misaligned mineral crystals,and altered osteoblast differentiation[J].骨研究（英文版）,2026,14(4):1099-1116,18.

基金项目

A special thanks to our HBM OI patient for his sustained interest in and contributions to our further research,and to Alberta Derkyi,NP,and Sara Talvacchio,RN of NICHD OCD for clinical management of the patient.We would like to thank Elena Evans for her excellent technical assistance in maintaining the mouse colony,Paul Roschger for his guidance with the BMDD measurements,and Petra Keplinger,Sonja Lueger,and Phaedra Messmer from the Bone Laboratory of the Ludwig Boltzmann Institute of Osteology in Vienna,Austria,for careful sample preparations and qBEI measure-ments.Stéphane Blouin and Nadja Fratzl-Zelman are members of the ERN BOND-the European Reference Network for rare Bone Diseases(https://ernbond.eu/).This research was supported by the AUVA(Research Funds of the Austrian workers'compensation board),the OEGK(Austrian Social Health Insurance Fund),and NICHD Intramural Funding to J.C.M.(ZIA HD008830-16).This research was supported by the Intramural Research Program of the National Institutes of Health(NIH).The contributions of the NIH authors are considered Works of the United States Government.The findings and conclusions presented in this paper are those of the authors and do not necessarily reflect the views of the NIH or the U.S.Department of Health and Human Services. （https://ernbond.eu/）

骨研究（英文版）

ISSN：2095-4700

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