We would like to thank Drs.Joe Giacolo and Yasuhide Furuta from the Mouse Genetics Core Facility at Memorial Sloan Kettering Cancer Center for their assistance with the generation of the Clec3bCreERT2 knock-in allele.We also thank Drs.Takashi Nagasawa,Noriaki Ono,and Matthew Greenblatt for providing additional genetically modified mouse strains.We thank Drs.Mohammed Hammad,Vincentius Suhardi,Xu Yang,and Mathias Bostrom at HSS for their assistance with surgical procedures,Ms.Samantha Lessard and Dr.Miguel Otero for their assistance with in vivo mechanical loading experiments,Drs.Elena Makareeva,Sergey Leikin,Chitra Dahia,and Sushmita Mukherjee for their assistance with RNAscope analysis,and Dr.April Craft for her guidance with the chondrogenic differentiation assay.This study was supported by grants from the S&L Marx Foundation,Giuliani Foundation,and Stavros Niarchos Complex Joint Reconstruction Center at Hospital for Special Surgery.Ezgi Aydin is supported by the Francis Glorieux Research Fellowship from the Canadian Osteogenesis Imperfecta Society.The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.The authors are grateful to the Tow Foundation for their support of David Rosensweig Genomics Center at Hospital for Special Surgery. （）