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An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells

Ali Jasim Mohammad Jamil Yuting Wang Eri Takematsu Liming Zhao Stuart Barry Goodman Lawrence Henry Goodnough Charles Kwok Fai Chan Thomas Levin Andersen Moustapha Kassem Alexander Rauch Kaja Madsen Souad Daamouch Birgitte Villadsen Chao Ma Shakespeare Jeromdesella Mikkel Ørnfeldt Nørgård Emilie Grupe Maria Bruun Jakobsson

骨研究(英文版)2026,Vol.14Issue(4):1131-1149,19.
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骨研究(英文版)2026,Vol.14Issue(4):1131-1149,19.DOI:10.1038/s41413-026-00536-2

An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells

An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells

Ali Jasim Mohammad Jamil 1Yuting Wang 2Eri Takematsu 2Liming Zhao 2Stuart Barry Goodman 3Lawrence Henry Goodnough 3Charles Kwok Fai Chan 2Thomas Levin Andersen 4Moustapha Kassem 5Alexander Rauch 6Kaja Madsen 1Souad Daamouch 1Birgitte Villadsen 4Chao Ma 7Shakespeare Jeromdesella 1Mikkel Ørnfeldt Nørgård 8Emilie Grupe 1Maria Bruun Jakobsson8

作者信息

  • 1. The Molecular Endocrinology&Stem Cell Research Unit(KMEB),Department of Endocrinology,Odense University Hospital,Odense,Denmark||Department of Clinical Research,University of Southern Denmark,Odense,Denmark
  • 2. Institute for Stem Cell Biology and Regenerative Medicine,Stanford University School of Medicine,Stanford,USA||Department of Surgery,Stanford University School of Medicine,Stanford,USA
  • 3. Department of Orthopedic Surgery,Stanford University School of Medicine,Stanford,USA
  • 4. Department of Clinical Research,Molecular Bone Histology(MBH)lab and Danish Spatial Imaging Consortium(DanSIC),University of Southern Denmark,Odense,Denmark||Department of Pathology,Odense University Hospital,Odense,Denmark
  • 5. The Molecular Endocrinology&Stem Cell Research Unit(KMEB),Department of Endocrinology,Odense University Hospital,Odense,Denmark||Department of Clinical Research,University of Southern Denmark,Odense,Denmark||Department of Cellular and Molecular Medicine,University of Copenhagen,Copenhagen,Denmark||College of Medicine and Health Sciences(CMHS)&Center for Biotechnology,Khalifa University,Abu Dhabi,UAE
  • 6. The Molecular Endocrinology&Stem Cell Research Unit(KMEB),Department of Endocrinology,Odense University Hospital,Odense,Denmark||Department of Clinical Research,University of Southern Denmark,Odense,Denmark||Steno Diabetes Center Odense,Odense University Hospital,Odense,Denmark
  • 7. Institute for Stem Cell Biology and Regenerative Medicine,Stanford University School of Medicine,Stanford,USA||Department of Orthopedic Surgery,Stanford University School of Medicine,Stanford,USA
  • 8. The Molecular Endocrinology&Stem Cell Research Unit(KMEB),Department of Endocrinology,Odense University Hospital,Odense,Denmark
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摘要

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Ali Jasim Mohammad Jamil,Yuting Wang,Eri Takematsu,Liming Zhao,Stuart Barry Goodman,Lawrence Henry Goodnough,Charles Kwok Fai Chan,Thomas Levin Andersen,Moustapha Kassem,Alexander Rauch,Kaja Madsen,Souad Daamouch,Birgitte Villadsen,Chao Ma,Shakespeare Jeromdesella,Mikkel Ørnfeldt Nørgård,Emilie Grupe,Maria Bruun Jakobsson..An ITGA11 expressing subpopulation as predictor for the donor-specific osteogenic capacity of stromal cells[J].骨研究(英文版),2026,14(4):1131-1149,19.

基金项目

Sequencing was carried out at the Villum Center for Bioanalytical Sciences,Functional Genomics&Metabolism Research Unit,University of Southern Denmark,and at the Clinical Genome Center,Odense University Hospital and University of Southern Denmark.We thank Ronni Nielsen and Zainab Hikmat for sequencing assistance.Flow cytometry and cell sorting were performed at the Danish Center for Advanced Cell Analysis,supported by the Novo Nordisk Foundation(0075258).Immune staining and in situ hybridization were performed with the help of Signe Marie Andersen at the Danish Spatial Imaging Consortium(DanSIC),funded by the Novo Nordisk Foundation(NNF22OC0075296).This work was supported by a grant from the Lundbeck Foundation(R335-2019-2195),Independent Research Fund Denmark(0134-00292B),Novo Nordisk Foundation(NNF22OC0078257)and the Odense University Hospital free research fund(98-A4534)to A.R.,a grant from the Danish 3R-center(33010-NIFA-21-760)and PhD scholarship from the Region of Southern Denmark to A.J.M.J.,and a grant from the Novo Nordisk foundation(NNF19OC0057449)to MK.Finally,we would like to dedicate a special thanks to the late Charles Kwok Fai Chan for his invaluable scientific guidance throughout the study. (0075258)

骨研究(英文版)

2095-4700

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