首页|期刊导航|骨研究（英文版）|Akkermansia muciniphila attenuates intervertebral disc degeneration via extracellular vesicle-mediated delivery of the effector protein B2UKX5

Akkermansia muciniphila attenuates intervertebral disc degeneration via extracellular vesicle-mediated delivery of the effector protein B2UKX5

Zhe Guan Zhilin Pang Yiwei Liu Ling Jin Shiyu Zeng Yi Luo Xiaoxiao Gong Yu Yang Ya Chen Yang Wu Meidan Wan Xiaoxue Li Hao Yin Yong Zhou Zhenxing Wang Hui Xie Yixiao Chen Sheng Zhu Jie Wen Hongliang Zhou Chunyuan Chen Jianghua Liu Guoqiang Zhu

骨研究（英文版）2026，Vol.14Issue(4)：1218-1236,19.

骨研究（英文版）2026，Vol.14Issue(4)：1218-1236,19.DOI:10.1038/s41413-026-00541-5

Akkermansia muciniphila attenuates intervertebral disc degeneration via extracellular vesicle-mediated delivery of the effector protein B2UKX5

Zhe Guan ¹Zhilin Pang ¹Yiwei Liu ¹Ling Jin ¹Shiyu Zeng ²Yi Luo ¹Xiaoxiao Gong ³Yu Yang ¹Ya Chen ¹Yang Wu ¹Meidan Wan ⁴Xiaoxue Li ⁵Hao Yin ¹Yong Zhou ⁶Zhenxing Wang ⁷Hui Xie ⁷Yixiao Chen ¹Sheng Zhu ¹Jie Wen ⁸Hongliang Zhou ¹Chunyuan Chen ¹Jianghua Liu ²Guoqiang Zhu¹

作者信息

1. Department of Orthopedics,Movement System Injury and Repair Research Center,Xiangya Hospital,Central South University,Changsha,Hunan,China||Hunan Key Laboratory of Angmedicine,Changsha,Hunan,China
2. The First Affiliated Hospital of University of South China,Hengyang,Hunan,China
3. Department of Respiratory Medicine,National Key Clinical Specialty,Branch of National Clinical Research Center for Respiratory Disease,Xiangya Hospital,Central South University,Changsha,Hunan,China
4. Department of Neurology,Xiangya Hospital,Central South University,Changsha,Hunan,China
5. Department of Gastroenterology,The First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,China
6. Third Xiangya Hospital,Central South University,Changsha,Hunan,China
7. Department of Orthopedics,Movement System Injury and Repair Research Center,Xiangya Hospital,Central South University,Changsha,Hunan,China||Hunan Key Laboratory of Angmedicine,Changsha,Hunan,China||National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha,Hunan,China
8. Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan,China
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摘要

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Zhe Guan,Zhilin Pang,Yiwei Liu,Ling Jin,Shiyu Zeng,Yi Luo,Xiaoxiao Gong,Yu Yang,Ya Chen,Yang Wu,Meidan Wan,Xiaoxue Li,Hao Yin,Yong Zhou,Zhenxing Wang,Hui Xie,Yixiao Chen,Sheng Zhu,Jie Wen,Hongliang Zhou,Chunyuan Chen,Jianghua Liu,Guoqiang Zhu..Akkermansia muciniphila attenuates intervertebral disc degeneration via extracellular vesicle-mediated delivery of the effector protein B2UKX5[J].骨研究（英文版）,2026,14(4):1218-1236,19.

基金项目

This work was supported by the National Natural Science Foundation of China(Grant No.82125023 to H Xie （）

82272562 to Z-X Wang （）

82372482 to Y Zhou),the Hunan Province Natural Science Foundation of China(Grant no.2023JJ20096 to Z-X Wang),the Science and Technology Innovation Program of Hunan Province(Grant no.2023RC3075 to Z-X Wang),the China Postdoctoral Science Foundation(Grant No.2024M7513252 to H Yin).Figures 1a,1f,2a,3a,3ml,4c,4l,6a,6j,7a,S5a,S6a,and S11a are generated using BioRender. （Grant no.2023JJ20096 to Z-X Wang）

骨研究（英文版）

ISSN：2095-4700

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