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Inhibition of AXL receptor tyrosine kinase increases osteoblast function and bone mass

Mubashir Ahmad Benjamin Thilo Krüger Sooyeon Lee Francesco Roselli Anita Ignatius Jan Tuckermann Christoph Kölbl Irfana Jan Ann-Kristin Dorn Burak Özkan Florian Olde Heuvel Dilay Yilmaz Alessa Wagner Maja Vujic Spasic

骨研究（英文版）2026，Vol.14Issue(4)：1263-1280,18.

骨研究（英文版）2026，Vol.14Issue(4)：1263-1280,18.DOI:10.1038/s41413-026-00554-0

Inhibition of AXL receptor tyrosine kinase increases osteoblast function and bone mass

Mubashir Ahmad ¹Benjamin Thilo Krüger ²Sooyeon Lee ³Francesco Roselli ⁴Anita Ignatius ²Jan Tuckermann ⁵Christoph Kölbl ²Irfana Jan ⁶Ann-Kristin Dorn ³Burak Özkan ⁷Florian Olde Heuvel ⁷Dilay Yilmaz ³Alessa Wagner ³Maja Vujic Spasic³

作者信息

1. Institute of Molecular Endocrinology and Physiology,Ulm University,Ulm,Germany||Institute of Orthopedic Research and Biomechanics,Ulm University Medical Center,Ulm,Germany
2. Institute of Orthopedic Research and Biomechanics,Ulm University Medical Center,Ulm,Germany
3. Institute of Molecular Endocrinology and Physiology,Ulm University,Ulm,Germany
4. Department of Neurology,Ulm University,Ulm,Germany||German Center for Neurodegenerative Disease(DZNE)-Ulm,Ulm,Germany
5. Institute of Molecular Endocrinology and Physiology,Ulm University,Ulm,Germany||German Center for Child and Adolescent Health(DZKJ),Partner Site Ulm,Ulm,Germany
6. Institute of Molecular Endocrinology and Physiology,Ulm University,Ulm,Germany||Institute of Immunology,Ulm University Medical Center,Ulm,Germany
7. Department of Neurology,Ulm University,Ulm,Germany
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摘要

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Mubashir Ahmad,Benjamin Thilo Krüger,Sooyeon Lee,Francesco Roselli,Anita Ignatius,Jan Tuckermann,Christoph Kölbl,Irfana Jan,Ann-Kristin Dorn,Burak Özkan,Florian Olde Heuvel,Dilay Yilmaz,Alessa Wagner,Maja Vujic Spasic..Inhibition of AXL receptor tyrosine kinase increases osteoblast function and bone mass[J].骨研究（英文版）,2026,14(4):1263-1280,18.

基金项目

We thank BerGenBio AS(Bergen,Norway)for generously providing BGB324.We thank the animal facility at Ulm University for their excellent support,with special appreciation to Birgit Widmann for her expert assistance.We are also grateful to Iris Baum and Ulrike Kelp for their outstanding technical support.This work was supported by grants from Deutsche Forschungsgemeinschaft(DFG)to J.T.,A.I.,and F.R.within the framework of the Collaborative Research Center CRC1149"Danger Response,Disturbance Factors and Regenerative Potential after Trauma"(Project No.251293561-CRC1149,INST 40/492-3),and a DFG grant to J.T.within the framework of Collaborative Research Center CRC1506"Aging at interfaces"(Project No.450627322)and Transregio TRR 369 DIONE"Degeneration of bone due to Inflammation"(Project No.501752319).F.R.and B.Ö.were also supported by the BMBF through the JPND program within the DC4MND consortium(grant no.BMBF-01ED2301).Additional funding was provided by the Federal Ministry of Research,Technology and Space(Bundesministerium für Forschung,Technologie und Raumfahrt,BMFTR)as part of the German Center for Child and Adolescent Health(DZKJ)under the funding code 01GL2407A.M.A.was supported by a Baustein grant(L.SBN.0224)from the Medical Faculty of Ulm University.Open Access funding enabled and organized by Projekt DEAL. （Bergen,Norway）

骨研究（英文版）

ISSN：2095-4700

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