We thank Heather Warnock and the staff of the Biological Research Facility(BRF)at the University of Edinburgh for providing invaluable animal support,Colin Wood and the staff at Easter Bush Pathology,Royal(Dick)School of Veterinary Studies,University of Edinburgh,for conducting mouse serum biochemistries.We acknowl-edge financial support from Chulabhorn Royal Academy to W.P.,the Biotechnology and Biological Sciences Research Council(BBSRC)for supporting LAS via a Discovery Fellowship(BB/X009904/1)and for Institute Strategic Programme Grant Funding BBS/E/RL/230001 C)to C.F.and S.N.J.We also acknowledge the R(D)SVS,University of Edinburgh,for studentship funding to RLW and the Medical Research Council for funding to KAS(MR/V033506/1 and MR/R022240/2)and WPC(MR/M021394/1 and MR/S010505/1).For the purpose of open access,the authors have applied a CC-BY public copyright license to any Author Accepted Manuscript version arising from this submission. （BRF）