Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling
Yuki Ogawa Masanari Hamasaki Daisuke Takahashi Koji Iwasaki Ken Kadoya Tomohiro Onodera Norimasa Iwasaki M.Alaa Terkawi Taku Ebata Taiki Tokuhiro Liyile Chen Ryota Suzuki Yuki Fujie Masaya Nakajo Tsutomu Endo Hend Alhasan
Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling
Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling
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Yuki Ogawa,Masanari Hamasaki,Daisuke Takahashi,Koji Iwasaki,Ken Kadoya,Tomohiro Onodera,Norimasa Iwasaki,M.Alaa Terkawi,Taku Ebata,Taiki Tokuhiro,Liyile Chen,Ryota Suzuki,Yuki Fujie,Masaya Nakajo,Tsutomu Endo,Hend Alhasan..Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling[J].骨研究（英文版）,2026,14(4):1296-1308,13.基金项目
This work was supported by the Japan Society for the Promotion of Science(Grant-in-Aid for Early-Career Scientists:21K16673 （）
Scientific Research B:23H03025),the Japan Agency for Medical Research and Development(Moonshot Research and Develop-ment Program,AMED Moonshot:JP21zf0127004),and the Kobayashi Foundation.The authors would like to thank the orthopedic surgeons at Hokkaido University Hospital who helped us to obtain samples from OA patients undergoing knee arthroplasty.The authors thank Professor Lynda F.Bonewald,Indiana Center for Musculoskeletal Health(ICMH,IN,USA),for providing MLO-Y4-like osteocytes and Dmp1-cre transgenic mice.Gsdmd floxed mice(RBRC10762)were provided by RIKEN BRC,which is participating in the National BioResource Project of the MEXT/AMED,Japan.Language editing assistance(ChatGPT （Moonshot Research and Develop-ment Program,AMED Moonshot:JP21zf0127004）
OpenAI)was used for English language and grammar correction without changing the meaning or content.Scientific illustrations and schematic diagrams were generated using BioRender under an academic license. （）
