广州中医药大学学报2026，Vol.43Issue(9)：2344-2355,12.DOI:10.13359/j.cnki.gzxbtcm.2026.09.005
特发性膜性肾病患者不同危险分层证候要素分布规律
Distribution Patterns of Syndrome Elements in Patients with Idiopathic Membranous Nephropathy at Different Risk Stratifications
摘要
Abstract
Objective To explore the distribution patterns of traditional Chinese medicine(TCM)symptoms and syndrome elements in patients with idiopathic membranous nephropathy(IMN),so as to provide clinical evidence for TCM syndrome differentiation and treatment of IMN.Methods Clinical data of 100 patients with IMN as the primary diagnosis who were treated in the outpatient and inpatient departments of Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine from May 2024 to May 2025 were prospectively collected for TCM syndrome element determination.Descriptive statistics and correlation analysis were used to explore the distribution characteristics of TCM symptoms and syndrome elements in IMN patients and their correlations with gender,age and 24-hour urinary total protein(24hUTP).Results Among 100 IMN patients,common symptoms included frothy urine(94.00%),fatigue(76.00%),edema(75.00%),lower back soreness(68.00%)and forgetfulness(60.00%).The main location syndrome elements were kidney(90.00%),spleen(67.00%)and liver(57.00%).The main nature syndrome elements were qi deficiency(77.00%),water retention(76.00%),dampness(64.00%),yin deficiency(62.00%),blood deficiency(62.00%),heat(55.00%)and blood stasis(46.00%).Correlation analysis showed that in terms of gender difference,the proportion of yang hyperactivity syndrome element in female patients was higher than that in male patients(P＜0.01).In terms of age,the proportion of blood deficiency syndrome element showed an increasing trend with age(P＜0.05).In addition,with the increase of proteinuria,the proportions of water retention,dampness,heat,blood stasis,phlegm and wind syndrome elements all showed increasing trends(P＜0.05 or P＜0.01),among which the severity of water retention syndrome,heat syndrome and blood stasis syndrome also showed increasing trends(P＜0.05 or P＜0.01).Conclusion IMN is a disease of intermingled deficiency and excess mainly characterized by qi deficiency,yin deficiency,blood deficiency,water retention,dampness,heat and blood stasis,with the main disease locations in the kidney,spleen and liver.The distribution of its syndrome elements has certain correlations with gender,age and degree of proteinuria.关键词
特发性膜性肾病/中医症状/证素/病位证素/病性证素/水停证/热证/血瘀证/虚实夹杂Key words
idiopathic membranous nephropathy(IMN)/traditional Chinese medicine symptoms/syndrome elements/location syndrome elements/nature syndrome elements/water retention syndrome/heat syndrome/blood stasis syndrome/intermingled deficiency and excess分类
医药卫生引用本文复制引用
孙卉,刘力嘉,易岚,王钢,邹燕勤,仲昱..特发性膜性肾病患者不同危险分层证候要素分布规律[J].广州中医药大学学报,2026,43(9):2344-2355,12.基金项目
江苏省中医药管理局中医药科技发展计划重点项目(编号:ZD202205) （编号:ZD202205）
江苏省研究生科研与实践创新计划项目(编号:SJCX24_0933) （编号:SJCX24_0933）
