海南医科大学学报2026，Vol.32Issue(17)：1327-1334,8.DOI:10.13210/j.cnki.jhmu.20250616.003
肝恶性肿瘤钇-90选择性内放射治疗后的影像评估
Imaging evaluation of liver malignancies after yttrium-90 selective internal radiation therapy
摘要
Abstract
Objective:To analyze the imaging findings and tumor remission after yttrium-90 selective internal radiotherapy(90Y-SIRT)for liver malignant tumors,and to explore the relationship between actual absorbed dose of tumor and tumor remission.Methods:The data of 44 patients with hepatic malignant tumors evaluated by 90Y PET/CT and MRI after 90Y-SIRT were collected,including 34 patients with primary hepatic malignant tumors(primary group)and 10 patients with secondary malignant tumors(secondary group).The characteristics between groups were compared using χ2 test.The curative effect was evaluated by mRE-CIST and RECIST1.1 criteria,and the remission rate of tumor on MRI was calculated.With the tumor response after 3 months as a reference,the diagnostic efficacy of MRI-DWI,MRI enhancement,and tumor markers in early efficacy evaluation was investi-gated.The relationship between actual absorbed dose of tumor and tumor remission was explored by Spearman correlation analy-sis.Results:One month after treatment,the remission rates of primary group and secondary group were 68.7%and 0.0%,respec-tively.After 3 months,the remission rates of primary group and secondary group were 72.2%and 40.0%,respectively,and those of 6 months were 83.3%and 33.3%,respectively.There was no correlation between the actual absorbed dose of tumor and imaging remission rate(ρ=0.061,P=0.764).One month after the treatment,the sensitivity of MRI-DWI,MRI enhancement,and tumor markers to evaluate tumor early response was 88.24%,73.33%,and 58.82%,respectively,and the specificity was 16.67%,71.43%,and 57.14%,respectively.Conclusion:There is a good imaging remission rate after 90Y-SIRT treatment for liver malig-nant tumors,and the remission rate in the primary group is higher than that in the secondary group.DWI and tumor markers have high sensitivity in reflecting the early response ability of the tumor,and there is no statistical correlation between the actual ab-sorbed dose of the tumor and imaging remission rate.关键词
肝脏肿瘤/钇-90/选择性内放射治疗/磁共振成像Key words
Liver tumor/Yttrium-90/Selective internal radiation therapy/Magnetic resonance imaging分类
医药卫生引用本文复制引用
林秀艳,于丽娟,王玉君,李雪艳,龚伟,孟凡盛,潘登..肝恶性肿瘤钇-90选择性内放射治疗后的影像评估[J].海南医科大学学报,2026,32(17):1327-1334,8.基金项目
This study was supported by the Health Industry Research Project of Hainan Province(22A200294) （22A200294）
Project of Hainan Clinical Medical Research Center(LCYX202403) 海南省卫生健康行业科研项目(22A200294) （LCYX202403）
海南省临床医学研究中心项目(LCYX202403) （LCYX202403）
