河南中医2026，Vol.46Issue(9)：1354-1358,5.DOI:10.16367/j.issn.1003-5028.2026.09.0222
运用子午流注理论防治糖尿病血糖波动
Prevention and Treatment of Blood-Glucose Fluctuation in Diabetes Mellitus Based on the Midnight-Noon Ebb-Flow Theory
摘要
Abstract
According to the midnightnoon ebbflow theory,when qiblood in the meridians reaches its peak period,the zang-fu essenceqi is the most abundant and visceral functions are at their strongest.Insufficient qiblood or impeded circulation may deprive zang-fu organs of nourishment prior to the arrival of qiblood,thereby triggering visceral dysfunction,a pathological condition defined as"overstrain of zang-fu organs before qiblood arrives".This mechanism can well explain the phenomenon of bloodglucose fluctuation in diabetes melli-tus.Patients with diabetesthirst disorder suffer from visceral dysfunction.When complicated with circadian rhythm disturbance and disor-dered qiblood flow,qiblood fails to arrive on time,leading to inadequate perfusion of qiblood during the peakactivity phase of zang-fu or-gans.Subsequently,the transportation and distribution of food essence are disturbed,and nutrients stagnate within vessels,resulting in elevated blood glucose.Delayed circulation of qiblood deprives zang-fu organs of nourishment and impairs their functions,hindering glu-cose utilization and consequently causing pathological hypoglycemia.Qistagnation and bloodstasis block the transportation and distribu-tion of nutrient essence,giving rise to persistently high blood glucose or unstable glycemic fluctuation.Preventing bloodglucose fluctua-tion needs to focus on restoring endogenous human circadian rhythm and holistic homeostasis via regular daily routines conforming to natural rhythms.According to the theory of midnight-noon ebb-flow,time-selection constitutes the core.Its advantage lies in developing individualized intervention regimens from the temporal dimension.Such regimens are implemented through multiple modalities including time-phased medication administration,external therapies,dietary regulation and timed physical exercise.They can complement the"fivecarriage"strategy of comprehensive diabetes management in modern medicine,so as to jointly stabilize bloodglucose fluctuation.关键词
糖尿病/血糖波动/子午流注理论/时间医学Key words
diabetes mellitus/bloodglucose fluctuation/midnightnoon ebbflow theory/time medicine分类
医药卫生引用本文复制引用
杨晶洁,刘添娇,徐菁晗,张琦,朴春丽..运用子午流注理论防治糖尿病血糖波动[J].河南中医,2026,46(9):1354-1358,5.基金项目
国家自然科学基金项目(82374280) （82374280）
广东省基础与应用基础研究基金项目(2023A1515220236) （2023A1515220236）
深圳市"医疗卫生三名工程"项目(SZZYSM202202010) （SZZYSM202202010）
深圳市科技计划项目(JCYJ20220531091409022,JCYJ20240813160612016) （JCYJ20220531091409022,JCYJ20240813160612016）
