解放军医学杂志2026，Vol.51Issue(8)：1168-1175,8.DOI:10.11855/j.issn.0577-7402.2646.2026.0525
高温对高尿酸血症患者勃起功能障碍影响的研究现状、热点述评与展望
Impact of high ambient temperature on erectile dysfunction in hyperuricemia patients:current status,hotspot review and future perspectives
李佳 1路永欣2
作者信息
- 1. 解放军南部战区总医院内分泌科,广东 广州 510010
- 2. 解放军南部战区总医院内分泌科,广东 广州 510010||南方医科大学第一临床医学院,广东 广州 510515
- 折叠
摘要
Abstract
Hyperuricemia(HUA)is one of the risk factors for erectile dysfunction(ED).By inducing vascular endothelial dysfunction,insulin resistance and other pathological processes,HUA forms a complex pathological network interwoven via the crosstalk among multiple pathways,which synergistically drives the onset and progression of ED.Existing evidence indicates that high ambient temperature can not only elevate serum uric acid levels,but also synergistically aggravate the risk of ED in HUA patients by activating pathways including the inflammasome pathway,the polyol-fructokinase pathway and the oxidative stress pathway.In this review,we summarize the epidemiological association and underlying pathological mechanisms between HUA and ED,focusing on the accelerator effect of high ambient temperature in the causal link between HUA and ED,and propose the novel hypothesis of"heat-HUA-ED"triad.Further studies are required to validate this hypothesis in animal models and explore targeted intervention strategies for these common pathways,such as nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,so as to provide novel insights from the cross-disciplinary field of environmental and metabolic research for the prevention and treatment of HUA complicated with ED.关键词
高尿酸血症/勃起功能障碍/高温环境Key words
hyperuricemia/erectile dysfunction/high ambient temperature分类
医药卫生引用本文复制引用
李佳,路永欣..高温对高尿酸血症患者勃起功能障碍影响的研究现状、热点述评与展望[J].解放军医学杂志,2026,51(8):1168-1175,8.
