中国健康心理学杂志2026，Vol.34Issue(9)：1307-1311,5.DOI:10.13342/j.cnki.cjhp.2026.09.006
肺癌化疗患者呼吸困难严重程度与抑郁症状的路径:疾病进展恐惧的双重中介作用
Pathway of respiratory distress severity and depressive symptoms in lung cancer chemotherapy patients:The dual mediating role of disease progression fear
摘要
Abstract
Objective:To explore the dual mediating role of the physiological health and social family dimensions of fear of disease progression(FoP)between the severity of respiratory distress and depressive symptoms in lung cancer chemotherapy patients.Methods:A total of 108 lung cancer chemotherapy patients admitted to our hospital from Jan-uary 2022 to January 2025 were selected as the study subjects.The general information questionnaire,Modified Medi-cal Research Council Dyspnea Scale(mMRC),Self Rating Depression Scale(SDS),and Simplified Fear of Disease Progression Scale(FoP-Q-SF)were used for evaluation,and the mediating effect of the fear of disease progression was examined using structural equation modeling and Bootstrap method.Results:The total score of mMRC scale was 31.68±7.42 points,indicating moderate to severe respiratory distress;The total score of SDS scale was 56.83±11.27 points,significantly higher than the critical value of depression(≥50 points);The total score of FoP-Q-SF scale was 40.96±8.42 points,and the score of physiological health dimension(22.59±5.13)was significantly higher than that of social family dimension(18.37±4.25).The severity of respiratory distress was significantly positively correla-ted with depressive symptoms(r=0.427,P＜0.001),and positively correlated with the total score of disease pro-gression fear(r=0.582,P＜0.01)and its physiological health dimension(r=0.436,P＜0.001),as well as the social and family dimension(r=0.294,P＜0.05).The total score of depression symptoms and disease progression fear(r=0.523,P＜0.001)and the dual dimensions(social and family dimension r=0.387,P＜0.01);The physiological health dimension r=0.473,P＜0.001)was positively correlated.The fear of disease progression played a dual mediating role between the severity of respiratory distress and depressive symptoms,with a total indirect effect accounting for 37.15％.Among them,the proportion of mediating pathways(effect value 0.117)in the dimension of physiological health fear(27.34％)was significantly higher than that in the dimension of social family fear(effect value 0.042,accounting for 9.81％).Conclusion:Fear of disease progression,especially in the physiological health dimension,is an important mediating pathway for the severity of respiratory distress in lung cancer chemotherapy patients to affect depressive symptoms.Clinically,patients' fear of disease progression,especially those related to physical health,should be man-aged in a targeted manner to block the psychological mechanism of depression caused by breathing difficulties and improve patients' mental health.关键词
肺癌化疗/呼吸困难严重程度/抑郁症状/疾病进展恐惧Key words
Chemotherapy for lung cancer/Severity of breathing difficulties/Depressive symptoms/Fear of pro-gression分类
医药卫生引用本文复制引用
黄娅琳,李唯媛,耿箐,李佳..肺癌化疗患者呼吸困难严重程度与抑郁症状的路径:疾病进展恐惧的双重中介作用[J].中国健康心理学杂志,2026,34(9):1307-1311,5.基金项目
2025年度河南省医学科技攻关计划联合共建项目(编号:LHCJ20250203) （编号:LHCJ20250203）
