实用临床医药杂志2026，Vol.30Issue(17)：8-16,9.DOI:10.7619/jcmp.20262822
原发性肝癌中医证素与临床指标相关性研究
Correlation study on traditional Chinese medicine syndrome elements and clinical indicators in primary liver cancer
摘要
Abstract
Objective To analyze the distribution pattern of traditional Chinese medicine(TCM)syndrome elements in patients with primary liver cancer through data mining,and to explore its correlation with clinical laboratory indicators.Methods In this retrospective study,clinical data of patients with primary liver cancer admitted to Dongfang Hospital,Beijing University of Chinese Medicine from January 2013 to January 2023 were collected.The distribution patterns of TCM syn-drome types,disease-location syndrome elements and disease-nature syndrome elements were ob-served.Association rules were applied to analyze the correlation rules of syndrome element distribu-tion,and the associations of core syndrome elements including"blood stasis"and"phlegm"with la-boratory indicators such as serum total bile acid(TBA),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),total bilirubin(TBIL)and high-density lipoprotein cholesterol(HDL-C)were investigated.Results A total of 138 patients with primary liver cancer were included in this study.The main syndrome types were liver depression and spleen deficiency,as well as intermingled phlegm and blood stasis,accounting for 52.17％.The disease-location syn-drome elements were mainly liver(39.93％)and spleen(39.21％),while the disease-nature syn-drome elements were mainly qi deficiency(24.60％),blood stasis(22.53％)and phlegm(20.69％).Association analysis showed that"spleen-qi deficiency""liver-phlegm"and"liver-blood stasis"were the strongest association rules.The levels of TBA,TC and LDL-C in the blood stasis group were significantly higher than those in the non-blood stasis group(P＜0.05).The lev-els of TG and TC in the phlegm group were significantly higher than those in the non-phlegm group(P＜0.05).Compared with the non-phlegm and non-blood stasisgroup,the levels of TC and TG in the phlegm and blood stasis group were significantly increased(P＜0.05);the TG level showed an increasing trend but the difference was not statistically significant(P=0.052 8).The TBA level in patients with blood stasis syndrome was significantly higher than that in patients without blood stasis syndrome(P＜0.05).Correlation analysis showed that in patients with"blood stasis"syndrome el-ement,TBA was positively correlated with TBIL and TG,and negatively correlated with HDL-C(P＜0.05).Conclusion TCM syndrome elements of patients with primary liver cancer are mainly qi deficiency,blood stasis and phlegm,which confirms the core pathogenesis of"deficiency in ori-gin and excess in superficiality"of liver cancer in TCM.Conventional laboratory indicators such as TBA,TC and TG have certain correlations with the syndrome elements of"blood stasis"and"phlegm",which are expected to become monitoring indicators for the objective evaluation of TCM syn-drome elements in liver cancer.The above findings provide an exploratory basis for the transformation of TCM syndrome differentiation from empirical judgment to objectification and standardization.关键词
原发性肝癌/中医证素/总胆汁酸/血脂异常/痰瘀互结/证候客观化/生物标志物/回顾性研究Key words
primary liver cancer/TCM syndrome element/total bile acid/dyslipidemia/inter-mingled phlegm and blood stasis/syndrome objectification/biomarker/retrospective study分类
医药卫生引用本文复制引用
杨丽惠,胡凯文,周天,吴华,李靖华,李一立,张水秀,王婧筱..原发性肝癌中医证素与临床指标相关性研究[J].实用临床医药杂志,2026,30(17):8-16,9.基金项目
国家自然科学基金(82104651) （82104651）
北京市科技新星计划(创新新星-王婧筱-2022041) （创新新星-王婧筱-2022041）
陕西省自然科学基金青年项目(2025JC-YBQN-1239) （2025JC-YBQN-1239）
西安市科协青年人才托举计划(959202413003) （959202413003）
