实用临床医药杂志2026，Vol.30Issue(17)：46-53,62,9.DOI:10.7619/jcmp.20262840
25-羟基维生素D、红细胞参数与铁代谢指标联合检测对0～18岁缺铁性贫血人群的预测价值
Predictive value of combined detection of 25-hydroxyvitamin D,erythrocyte parameters and iron metabolism indicators for iron deficiency anemia in people aged 0-18 years
摘要
Abstract
Objective To investigate the value of combined detection of 25-hydroxyvitamin D[25-(OH)D],erythrocyte parameters,and iron metabolism indicators in the diagnosis of iron defi-ciency anemia(IDA)in people aged 0-18 years.Methods A total of 75 people aged 0 to 18 years with confirmed IDA and 75 healthy controls were enrolled.All subjects were further divided into pre-school group(0 to 6 years)and school-age group(7 to 18 years)according to age.Serum levels of 25-(OH)D,hemoglobin(Hb),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),transferrin saturation(TS),serumferritin(SF),and transferrin(TRF)were measured in each group.Independent-sample non-parametric tests were performed,and receiver operating characteristic(ROC)curves were plotted to evaluate the diagnostic value of different indicators for IDA across dif-ferent age groups,with the aim of establishing distinct screening algorithms.Results In IDA group,the levels of 25-(OH)D,Hb,MCV,MCH,SF,and TS were significantly lower than those in the control subgroup,while TRF levels were significantly higher(P＜0.05).In the overall sam-ple aged 0 to 18 years,25-(OH)D was identified as an independent predictor of IDA(OR=0.960,P=0.017).Age-stratified analysis revealed that 25-(OH)D was not significant in univari-ate analysis in the preschool group and thus was not included in the multivariate independent predic-tion model;in the school-age group,25-(OH)D showed no independent diagnostic value in multi-variate analysis(P=0.170).The area under the ROC curve of the optimal combined diagnostic model was 0.881,0.873,and 0.885 for the preschool group,school-age group,and the overall 0 to 18 years group,respectively,which were significantly higher than those of any single indicator.Conclusion The optimal diagnostic models for IDA patients exhibit marked heterogeneity across different age groups.25-(OH)D demonstrates independent predictive value only in the overall 0 to 18 years population,but has no independent predictive value after stratification in both the preschool and school-age subgroups.Age-stratified combined detection can effectively compensate for the diag-nostic limitations of single indicators and provide a reliable laboratory basis for early and precise clinical diagnosis.关键词
缺铁性贫血/25羟基维生素D/血红蛋白/平均红细胞体积/转铁蛋白饱和度/血清铁蛋白/转铁蛋白/联合诊断Key words
iron deficiency anemia/25-hydroxyvitamin D/hemoglobin/mean corpuscular vol-ume/transferrin saturation/serum ferritin/transferrin/combined diagnosis分类
医药卫生引用本文复制引用
赵熙,樊文辉,靳伟舰,刘杰,马贤纵,常帅..25-羟基维生素D、红细胞参数与铁代谢指标联合检测对0～18岁缺铁性贫血人群的预测价值[J].实用临床医药杂志,2026,30(17):46-53,62,9.基金项目
国家自然科学基金资助项目(82500685) （82500685）
