菌物学报2026，Vol.45Issue(9)：1-27,27.DOI:10.13346/j.mycosystema.260127
硫黄菌活性成分及其药理作用研究进展
Research progress on chemical substance and pharmacological activities of Laetiporus sulphureus
摘要
Abstract
Laetiporus sulphureus is an edible and medicinal macrofungus widely distributed in temperate regions,typically parasitizing broadleaf trees and possessing significant nutritional,economic,and ecological value.In recent years,with the growing interest in natural products and functional foods,this fungus has attracted considerable attention due to its diverse chemical constituents and notable biological activities.Studies have shown that its fruiting bodies and mycelia are rich in various bioactive compounds,including polysaccharides,triterpenoids,sterols,sesquiterpenes,and polyphenols.These constituents exhibit a wide range of pharmacological activities,such as antitumor,anti-inflammatory,antioxidant,immunomodulatory,and metabolic regulatory effects.This review systematically summarizes the major classes and structural characteristics of these chemical constituents from L.sulphureus.Particular emphasis is placed on their pharmacological activities,especially antitumor and anti-inflammatory effects,along with the underlying molecular mechanisms,including the regulation of oxidative stress,inflammatory signaling pathways,and apoptosis.In addition,current limitations,such as insufficient studies on active substances,unclear mechanisms of action,and lack of clinical evidence,are critically discussed.Finally,future perspectives on the application of L.sulphureus in drug discovery and functional food development are proposed,aiming at providing a theoretical basis for its further research and high-value utilization.关键词
硫黄菌/活性成分/药理作用/作用机制Key words
Laetiporus sulphureus/active constituents/pharmacological activities/mechanisms of action引用本文复制引用
杜宏涛,王思雨,张洋,张向红,贺晓龙,张向前,马芳..硫黄菌活性成分及其药理作用研究进展[J].菌物学报,2026,45(9):1-27,27.基金项目
陕西省重点研发计划项目(2025NC-YBXM-078) （2025NC-YBXM-078）
陕西省教育厅重点科学研究计划项目(24JR165) （24JR165）
延安大学大学生创新创业训练计划(D2024158) This work was supported by the Key Research and Development Program of Shaanxi(2025NC-YBXM-078),the Shaanxi Provincial Education Department Key Research Program(24JR165),and the Innovation Training Program for College Students of Yan'an University(D2024158). （D2024158）
