检验医学与临床2026，Vol.23Issue(17)：2305-2310,2317,7.DOI:10.3969/j.issn.1672-9455.2026.17.001
血清ALB、CRP、FeNO对慢性阻塞性肺疾病急性加重期患者预后不良的预测价值
Predictive value of serum ALB,CRP and FeNO for the poor prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the predictive value of serum albumin(ALB),C reactive protein(CRP)and fractional exhaled nitric oxide(FeNO)on the poor prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 120 patients with AECOPD admitted to Tianshui First People's Hospital from February 2024 to April 2025 were selected as the AECOPD group.At the same time,120 healthy people who underwent physical examination in Tianshui First People's Hospital of Gansu Province were selected as the control group.Baseline data of all patients were collected.The levels of serum ALB,CRP and FeNO were detected in all subjects.According to the prognosis of AECOPD patients,they were divided into good prognosis group and poor prognosis group.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in AECOPD patients.The receiver operating charac-teristic(ROC)curve was drawn to analyze the predictive value of serum ALB,hs-CRP,FeNO alone and the combination of the three for poor prognosis in AECOPD patients.Results The serum ALB level of the AE-COPD group was lower than that of the control group,and the serum CRP and FeNO levels were higher than those of the control group,and the differences were statistically significant(P＜0.05).There were 77 cases in the good prognosis group and 43 cases in the poor prognosis group.The levels of forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),and serum ALB in the poor prognosis group were lower than those in the good prognosis group,and the levels of serum CRP and FeNO were higher than those in the good prognosis group,and the differences were statistically significant(P＜0.05).Multivariate Logistic re-gression analysis showed that the increased levels of serum CRP and FeNO were risk factors for poor progno-sis in patients with AECOPD(P＜0.05),and the increased levels of serum FVC,FEV1 and ALB were protec-tive factors for poor prognosis in patients with AECOPD(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum ALB,CRP,FeNO alone and the combination of the three to predict poor prognosis of AECOPD patients were 0.820,0.803,0.777,0.927,respectively.The AUC of combined prediction was greater than that of individual prediction(Z=3.006,3.508,4.005,P＜0.05).Conclusion The combined detection of serum ALB,CRP and FeNO has a high predictive value for the poor prognosis of AE-COPD patients,which is worthy of clinical application.关键词
清蛋白/C反应蛋白/呼出气一氧化氮/慢性阻塞性肺疾病急性加重期/预测价值Key words
albumin/C reactive protein/exhaled nitric oxide/acute exacerbation of chronic obstruc-tive pulmonary disease/predictive value分类
医药卫生引用本文复制引用
陈婷婷,祝俊年,陈娇,杨全福..血清ALB、CRP、FeNO对慢性阻塞性肺疾病急性加重期患者预后不良的预测价值[J].检验医学与临床,2026,23(17):2305-2310,2317,7.基金项目
甘肃省科技计划项目(23JRRA0984). （23JRRA0984）
