检验医学与临床2026，Vol.23Issue(18)：2449-2453,2461,6.DOI:10.3969/j.issn.1672-9455.2026.18.001
血细胞衍生指标与神经母细胞瘤患儿2年死亡风险的关系
Association of blood cell-derived indices with 2-year mortality risk in children with neuroblastoma
摘要
Abstract
Objective To investigate the associations of blood cell-derived indices[the neutrophil-to-lym-phocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and systemic immune-inflammation index(SII)]with the risk of 2-year mortality in children with neuroblastoma(NB).Methods A single-center retrospective cohort study was conducted involving 160 children with NB who were newly diagnosed and received standard-ized treatment at the hospital from January 2022 to December 2023.Baseline data and survival outcomes with-in 2 years were obtained from existing medical records and follow-up records.According to their survival out-comes within 2 years,the NB children were divided into a death group and a survival group.NLR,PLR,SII and baseline characteristics were compared between the two groups.Multivariate Logistic regression analysis was performed to identify influencing factors for 2-year mortality in children with NB.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of blood cell-derived indi-ces for 2-year mortality in children with NB.Results During the 2-year follow-up,41 of the 160 children died and 119 survived.Peripheral blood NLR,PLR,SII,neutrophil count(NE),platelet count(PLT)and the pro-portion of NB children with International Neuroblastoma Staging System(INSS)stage Ⅲ-Ⅳ disease were significantly higher in the death group than those in the survival group(P<0.05),whereas the lymphocyte count(LYM)was significantly lower(P<0.05).Multivariate Logistic regression analysis showed that INSS stage Ⅲ-Ⅳ disease and elevated PLR,NLR and SII were risk factors for 2-year mortality in children with NB(P<0.05).ROC curve analysis showed that the areas under the curves(AUCs)of PLR,NLR,and SII indi-vidually and in combination for predicting 2-year mortality in children with NB were 0.752(0.677-0.817),0.793(0.722-0.853),0.812(0.799-0.834)and 0.960(0.917-0.985)respectively.The AUC of the three-index combination was significantly greater than those of PLR,NLR,and SII individually(Z=3.685,4.378,and 5.121,respectively;all P<0.05).Conclusion Elevated PLR,NLR,and SII are associated with an increased risk of 2-year mortality in children with NB.The combination of the three indices improves the pre-dictive performance for 2-year mortality in this population.关键词
神经母细胞瘤/中性粒细胞与淋巴细胞比值/血小板与淋巴细胞比值/系统性免疫炎症指数/儿童/死亡Key words
neuroblastoma/neutrophil-to-lymphocyte ratio/platelet-to-lymphocyte ratio/systemic immune-inflammation index/children/mortality分类
医药卫生引用本文复制引用
鲍文澜,李超,武志祥,蒋马伟..血细胞衍生指标与神经母细胞瘤患儿2年死亡风险的关系[J].检验医学与临床,2026,23(18):2449-2453,2461,6.基金项目
国家自然科学基金项目(82472715). （82472715）
