临床肝胆病杂志2026，Vol.42Issue(8)：1755-1760,6.DOI:10.12449/JCH260803
酒精性肝病相关慢加急性肝衰竭:机制、动态评估与精准管理
Alcohol-related liver disease-associated acute-on-chronic liver failure:Mechanisms,dynamic assessment,and precise management
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is a high-mortality syndrome that develops during the acute deterioration of chronic liver disease and is characterized by multiple organ dysfunction driven by systemic inflammation.Due to gut microbiota dysbiosis,endotoxin translocation,and amplified inflammatory responses,alcohol-related liver disease-associated ACLF(ALD-ACLF)is more pronounced and is often accompanied by a high risk of secondary infection and extrahepatic organ involvement,thereby exhibiting distinct etiological and clinical characteristics.This article systematically reviews the advances in the definitional boundaries,pathophysiological mechanisms,dynamic early warning,and prognostic assessment of ALD-ACLF,elaborates on risk stratification and key issues in clinical management,and discusses the potential impact of the dual-hit phenotype of metabolic dysfunction and alcohol-related liver disease on risk stratification in ALD-ACLF.This article also highlights the need to further strengthen etiology-oriented early identification,dynamic stratification,control of predisposing factors,and earlier intervention,in order to provide a reference for the precise assessment and individualized intervention of these patients.关键词
慢加急性肝功能衰竭/肝疾病,酒精性/疾病管理Key words
Acute-On-Chronic Liver Failure/Liver Diseases,Alcoholic/Disease Management引用本文复制引用
艾娜,崔怀宁,方晓慧,柳涛,高沿航..酒精性肝病相关慢加急性肝衰竭:机制、动态评估与精准管理[J].临床肝胆病杂志,2026,42(8):1755-1760,6.基金项目
国家自然科学基金(U24A20654) （U24A20654）
吉林省自然科学基金自由探索重点项目(YDZJ202401427ZYTS) （YDZJ202401427ZYTS）
吉林省肝脏代谢重点实验室(YDZJ202502CXJD002) （YDZJ202502CXJD002）
吉林省全国重点实验室(学科类)重大专项(BRI202602001GH) （学科类）
国家重点研发计划(2024YFE0213800)National Natural Science Foundation of China(U24A20654) （2024YFE0213800）
Natural Science Foundation for Self-Exploration Research of Jilin Province(YDZJ202401427ZYTS) （YDZJ202401427ZYTS）
Jilin Provincial Key Laboratory of Metabolic Liver Diseases(YDZJ202502CXJD002) （YDZJ202502CXJD002）
Major Special Project of the National Key Laboratory of Jilin Province(BRI202602001GH) （BRI202602001GH）
National Key Research and Development Program of China(2024YFE0213800) （2024YFE0213800）
