临床肝胆病杂志2026，Vol.42Issue(8)：1766-1772,7.DOI:10.12449/JCH260805
慢加急性肝衰竭动物模型的研究进展:从两阶段构建到三阶段全病程模拟
Research advances in animal models of acute-on-chronic liver failure:From two-stage modeling to three-stage full-course simulation
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is a severe clinical syndrome characterized by acute decompensation of liver function,extrahepatic organ injury,and a high short-term mortality rate,with a complex pathogenesis that has not yet been fully clarified.Animal models of ACLF play a crucial role in disease research,since they not only provide a solid foundation for mechanistic studies,but also offer experimental evidence for clinical practice,thereby helping to promote advances in diagnosis and treatment.This article systematically reviews the commonly used animal models of ACLF,compares the establishment methods,pathophysiological characteristics,advantages,and limitations of different models,and discusses the latest research advances in animal models and innovative therapeutic strategies in the field,in order to provide a reference for further optimization,standardization,and application of animal models for ACLF.关键词
慢加急性肝功能衰竭/模型,动物/病理过程Key words
Acute-On-Chronic Liver Failure/Models,Animal/Pathologic Processes引用本文复制引用
陆嘉,卢捷,项晓刚..慢加急性肝衰竭动物模型的研究进展:从两阶段构建到三阶段全病程模拟[J].临床肝胆病杂志,2026,42(8):1766-1772,7.基金项目
国家自然科学基金(82570730,82170619,81970544) （82570730,82170619,81970544）
上海市东方英才计划拔尖人才项目(BJJY2024072) （BJJY2024072）
上海市公共卫生体系建设三年行动计划(2023-2025年)学科带头人项目(GWVI-11.2-XD03) National Natural Science Foundation of China(82570730,82170619,81970544) （2023-2025年）
Shanghai Oriental Talents Program Top-notch Talent Project(BJJY2024072) （BJJY2024072）
Project for Discipline Leaders in the Three-year Action Plan(2023-2025)for Strengthening the Construction of Public Health System in Shanghai(GWVI-11.2-XD03) （2023-2025）
