临床口腔医学杂志2026，Vol.42Issue(9)：519-526,8.DOI:10.3969/j.issn.1003-1634.2026.09.003
仿生矿化硒掺杂羟基磷灰石负载GelMA水凝胶复合体系促进牙周炎性骨缺损修复
A biomimetically mineralized selenium-doped hydroxyapatite-loaded GelMA composite hydrogel for repairing periodontitis-associated inflammatory bone defects
刘宇晴 1雷皓淇 1陈莉莉1
作者信息
- 1. 华中科技大学同济医学院附属协和医院口腔科 湖北 武汉 430022
- 折叠
摘要
Abstract
Objective:To construct a Se-HA/GelMA composite hydrogel and evaluate its effect on the repair of peri-odontitis-associated bone defects.Methods:Se-HA/GelMA hydrogel was prepared and characterized.In vitro,its effects on osteogenic differentiation and reactive oxygen species(ROS)levels in MC3T3-E1 cells,as well as macrophage polarization in RAW264.7 cells,were evaluated.In vivo,a rat model of periodontitis-associated bone defects was established to assess bone repair and local inflammatory changes.Results:Se-HA/GelMA showed favorable gelation performance,reduced ROS levels,promoted osteogenesis-related marker expression,regulated macrophage polarization toward the M2 phenotype,and improved bone microstructure in the defect area.Conclusion:Se-HA/GelMA exhibits antioxidative,immunomodulatory,and pro-osteo-genic effects,and may promote the repair of periodontitis-associated bone defects.关键词
硒掺杂羟基磷灰石/GelMA水凝胶/牙周炎/氧化应激/巨噬细胞极化/骨修复Key words
Selenium-doped hydroxyapatite/GelMA hydrogel/Periodontitis/Oxidative stress/Macrophage polariza-tion/Bone regeneration分类
医药卫生引用本文复制引用
刘宇晴,雷皓淇,陈莉莉..仿生矿化硒掺杂羟基磷灰石负载GelMA水凝胶复合体系促进牙周炎性骨缺损修复[J].临床口腔医学杂志,2026,42(9):519-526,8.
