翟晓羽 1宗志峰 1李俊枝 1要青清 1侯林静 1王红燕 1姜璐璐1
作者信息
- 1. 056004 河北邯郸,河北省邯郸市第一医院
- 折叠
摘要
Abstract
Objective To discuss the relationship between serum Delta like ligand 4(DLL4),vasohibin-1(VASH-1),C1q tumor necrosis factor related protein 9(CTRP9)and secondary macular edema in patients with retinal vein occlusion,and their impact on prognosis.Methods A prospective case-control study.109 patients with retinal vein occlu-sion and secondary macular edema who were admitted to our hospital from March 2023 to November 2024 were included as the macular edema group.Complying with the degree of macular edema,they were assigned into the mild edema group(na=48),the moderate edema group(n=35),and the severe edema group(n=26).Another 109 patients with simple retinal vein occlusion in our hospital were served as the retinal vein occlusion group,and 109 healthy individuals who underwent physi-cal check ups were served as the healthy control group.Enzyme linked immunosorbent assay was used to detect serum DLL4,VASH-1,and CTRP9.Complying with the visual recovery of patients after three months of treatment,the macular edema group was classified into the good prognosis group and the poor prognosis group.The receiver operating characteris-tic(ROC)curve was plotted to analyze the efficacy of serum DLL4,VASH-1,and CTRP9 in predicting the prognosis of pa-tients with retinal vein occlusion and secondary macular edema.Multivariate Logistic regression was used to analyze the prognostic factors of secondary macular edema in patients with retinal vein occlusion.Results Serum DLL4 and VASH-1 increased sequentially in the healthy control group,retinal vein occlusion group,and macular edema group,while CTRP9 decreased sequentially(all P＜0.05).Serum DLL4 and VASH-1 increased sequentially in the mild edema group,the moder-ate edema groupand the severe edema group,while CTRP9 decreased sequentially(all P＜0.05).The poor prognosis group had higher diastolic blood pressure,serum DLL4,and VASH-1,and lower CTRP9 than the good prognosis group(all P＜0.05).The area under the curve(AUC)values for predicting the prognosis of patients with retinal vein occlusion and second-ary macular edema using serum DLL4,VASH-1,and CTRP9 separately or their joint were 0.834,0.845,0.841,and 0.949,re-spectively,the AUC predicted by their joint was higher than that separate predictions(Z=3.423,4.490,4.374,all P＜0.05).Multivariate logistic regression analysis showed that serum DLL4,VASH-1,and CTRP9 were influencing factors for the prognosis of patients with retinal vein occlusion and secondary macular edema(all P＜0.05).Conclusions Serum DLL4 and VASH-1 are elevated,and CTRP9 is decreased in patients with retinal vein occlusion and secondary macular edema,and they can serve as potential biological indicators for predicting the prognosis of patients with retinal vein occlusion and secondary macular edema.关键词
视网膜静脉阻塞/黄斑水肿/Delta样配体4/血管生成抑制蛋白-1/C1q肿瘤坏死因子相关蛋白9/预后Key words
Retinal vein occlusion/Macular edema/Delta like ligand 4/Vasohibin-1/C1q tumor necrosis factor related protein 9/Prognosis
