摘要
Abstract
Objective To explore the etiology,clinical manifestations,treatment and prognosis of corneal epi-thelial dysfunction.Methods A retrospective case series study.33 eyes of 29 patients who were diagnosed with corneal epithelial dysfunction in the ophthalmology clinic of Wuhan Union Medical College Hospital were collected.There were 10 males(11 eyes)and 19 females(22 eyes),aged from(24～81)years,as well as(52±17)years.The general condition of all patients,characteristics and signs of ocular symptoms,characteristics of the confocal microscope images,and treatment methods were analyzed.Results 8 patients developed after eye surgery.2 patients had a history of diabetes.4 patients had physical or chemical trauma.3 patients had eyelid diseases,including stye,meibomian gland dysfunction,blepharitis,and dysraphism of the eyelids.There were 4 patients with dry eye,one of whom had sjogren's syndrome,4 patients had long-term use of multiple eye drops due to eye disease,and 1 patient had a contact lens wearing history of 8 years.Other causes included oral glucocorticoids and oral antidepressants.No pathogenic factors were found in 8 patients.The characteristics of corneal epithelial lesions included punctate corneal erosion,false dendritic opacities,local defects of corneal epithelium and corneal ulcers.All patients were cured or improved after the treatment.Conclusions Careful inquiry into the history and finding the cause of the disease can avoid misdiagnosis and disease persistence.Depending on the degree of keratopa-thy,use of drugs to promote corneal epithelial repair,as well as the necessary surgical treatment,can lead to a good progno-sis.关键词
角膜上皮功能障碍/角膜共聚焦显微镜/自体血清/羊膜移植Key words
Corneal epithelial dysfunction/Corneal confocal microscope/Autoserum/Amniotic membrane trans-plantation
