岭南现代临床外科2026，Vol.26Issue(4)：207-214,8.DOI:10.3969/j.issn.1009-976X.2026.04.001
乳腺浸润性微乳头状癌的临床病理特征及预后影响因素
Clinicopathological features and prognostic factors of breast invasive micropapillary carcinoma
摘要
Abstract
Objective To investigate the clinicopathological features and survival of invasive micro-papillary carcinoma(IMPC)of the breast.We compared pure-type IMPC with mixed-type IMPC in clini-copathological characteristics,disease-free survival(DFS),and overall survival(OS),and further as-sessed the prognostic impact of a 75%IMPC proportion threshold.Methods We retrospectively reviewed the clinicopathological and follow-up data of 230 patients with breast IMPC treated at Sun Yat-sen Memo-rial Hospital,Sun Yat-sen University,from January 2005 to October 2025.Pure-type IMPC was defined as a micropapillary component accounting for 100%of the invasive carcinoma(n=104);mixed-type IMPC was defined as IMPC admixed with other invasive carcinoma components(n=126).Patients were also stratified by a 75%threshold into an IMPC≤75%group(n=96)and an IMPC>75%group(n=134).Clinicopathological features and factors influencing DFS and OS were compared between the groups.Results The ER positivity rate differed significantly between pure-type and mixed-type IMPC.The overall 5-year DFS rate was 76.2%,and the 10-year OS rate was 67.8%.The 5-year DFS rates were 67.1%and 82.5%for pure-type and mixed-type IMPC,respectively(P=0.066);the 10-year OS rates were 61.4%and 73.8%(P=0.352).The 5-year DFS rates(82.4%vs.70.7%)and 10-year OS rates(79.1%vs.63.0%)did not differ significantly between the IMPC≤75%and IMPC>75%groups.Multivariable analysis showed that TNM stage(HR=7.320,95%CI:3.473～15.428,P<0.001)and endocrine therapy(HR=0.391,95%CI:0.166～0.919,P=0.031)were independent factors for DFS,and TNM stage(HR=6.628,95%CI:2.407～18.251,P<0.001)was an independent factor for OS.Conclusion Although the 5-year DFS and 10-year OS rates were numerically lower in pure-type than in mixed-type IMPC,neither difference was statistically significant.In clinical practice,TNM stage assessment should be emphasized,and endocrine therapy should be actively considered for hormone receptor-positive patients to improve DFS.关键词
浸润性微乳头状癌/乳腺癌/临床病理特征/预后/影响因素Key words
invasive micropapillary carcinoma/breast cancer/clinicopathological characteristics/prognosis/influencing factors分类
医药卫生引用本文复制引用
柴洁,丁林潇潇,王丽丽,陈韬,王君妍,蔡阳阳..乳腺浸润性微乳头状癌的临床病理特征及预后影响因素[J].岭南现代临床外科,2026,26(4):207-214,8.基金项目
国家自然科学基金项目(82271793 （）
82573593 （）
82573479 （）
82203141) （）
广州市科技计划项目(SL2023A03J01150 （）
2024A03J1195 （）
2025A03J4194) （）
中国抗癌协会-HER-2靶点中国科研基金(CORP-239-S10) （CORP-239-S10）
逸仙临床研究培育项目(SYS-Q-202101) （SYS-Q-202101）
逸仙临床研究5010计划(SYS-5010-202308、SYS-5010-202409) （SYS-5010-202308、SYS-5010-202409）
中山大学5010计划项目(81000-13130007) （81000-13130007）
广东省乳腺疾病临床医学研究中心(2023B110005) （2023B110005）
国家科技重大专项(2024ZD0519800 （）
2024ZD0519805) （）
逸仙科研启航项目(SYSQH-II-2026-06) （SYSQH-II-2026-06）
中国抗癌协会临床研究基金会(CETS-DSSCORP239-055) （CETS-DSSCORP239-055）
