南京医科大学学报（自然科学版）2026，Vol.46Issue(9)：1286-1293,8.DOI:10.7655/NYDXBNSN260201
呼吸事件相关的血氧饱和度下降速率与2型糖尿病及其血管并发症的相关性研究
A study on the correlation between respiratory event-related oxygen desaturation rate and type 2 diabetes mellitus with diabetic vascular complications
摘要
Abstract
Objective:To investigate the correlation between the oxygen desaturation rate(ODR)associated with obstructive respiratory events and type 2 diabetes mellitus(T2DM)as well as its vascular complications in patients with obstructive sleep apnea(OSA).Methods:A total of 493 patients with OSA who underwent polysomnography(PSG)at the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University between June 2023 and December 2024 were retrospectively included.Patients were divided into two groups:the T2DM group(n=218)and the non-T2DM group(n=275).Based on the peripheral oxygen saturation(SpO2)signal from PSG,event-level ODR(ΔSpOa/Δt)associated with obstructive respiratory events was calculated;individual-level ODR was defined as the median across all-night events.Participants were stratified into tertiles according to ODR(with the Low-ODR group as reference),and a multivariable logistic regression model was constructed to assess the associations of ODR and conventional PSG parameters with the risk of T2DM and diabetic vascular complications.Results:There were no significant differences in age,apnea-hypopnea index(AHI),or oxygen desaturation index(ODI)between the two groups.However,the ODR was significantly higher in the T2DM group than that in the non-T2DM group[0.50(0.35,0.67)％/s vs.0.38(0.29,0.52)％/s,P＜0.001].Multivariable logistic regression analysis showed that,High-ODR was significantly associated with T2DM(OR=2.96,95％CI:1.73-5.09,P＜0.001)and diabetic vascular complications(OR=3.91,95％CI:1.04-14.66,P＜0.05).Stratified analysis by sex further revealed that the association between ODR and the risk of T2DM was statistically significant only in male patients;the OR for T2DM in the males of High-ODR group was 3.64 times of the males in Low-ODR group(OR=3.64,95％CI:1.78-7.43,P＜0.001).Conclusion:ODR is significantly associated with T2DM and its vascular complications in patients with OSA,and this association exhibits gender-related differences.关键词
血氧饱和度下降速率/阻塞性睡眠呼吸暂停/2型糖尿病/糖尿病血管并发症Key words
oxygen desaturation rate/obstructive sleep apnea/type 2 diabetes mellitus/diabetic vascular complication分类
医药卫生引用本文复制引用
万玉姣,纪大鹏,袁玉洁,魏桂红,马其云,顾艳利,徐靖..呼吸事件相关的血氧饱和度下降速率与2型糖尿病及其血管并发症的相关性研究[J].南京医科大学学报（自然科学版）,2026,46(9):1286-1293,8.基金项目
国家自然科学基金(82370089) （82370089）
