南京医科大学学报（自然科学版）2026，Vol.46Issue(9)：1294-1302,9.DOI:10.7655/NYDXBNSN260282
C肽在1型糖尿病周围神经病变中的保护机制和临床前景
The protective mechanism and clinical prospects of C-peptide in peripheral neuropathy in type 1 diabetes mellitus
摘要
Abstract
Objective:The C-peptide is a by-product of proinsulin cleavage with recently identified probable pleiotropic protective effects in type 1 diabetic peripheral neuropathy(DPN).Up to now,through its physiological mechanisms like activating nitric oxide synthase,Na+/K+-ATPase and inhibiting nuclear factor kappa-B pathway,C-peptide can not only improve nerve blood flow and alleviate axonal injury,but also have antioxidant and anti-apoptotic effects.Apart from the molecular mechanism level,animal experiments showed that C-peptide could significantly improve nerve conduction velocity,blood flow and structural abnormalities in diabetic rats.Clinical trials have also shown that C-peptide replacement therapy improves nerve conduction velocity and vibration sensation in patients,and the long-acting formulation Peg-C peptide has more promise.Therefore,C-peptide may have a potential protective effect and clinical application prospect in type 1DPN.Although it has been proven that C-peptide has an effective role in improving neurological function,its mechanism in the treatment of neuropathic pain has not yet been specifically elucidated.Furthermore,its effect on neuropathic pain symptoms,optimal dosing regimen,and effect on intraepidermalnerve fiber density(IENFD)still need further study.关键词
C肽/周围神经病变/1型糖尿病Key words
C-peptide/peripheral neuropathy/type 1 diabetes分类
医药卫生引用本文复制引用
胡羽珊,王远远,潘寅兵..C肽在1型糖尿病周围神经病变中的保护机制和临床前景[J].南京医科大学学报（自然科学版）,2026,46(9):1294-1302,9.基金项目
伊犁与江苏省联合卫生研究院江苏省联合项目(yl2022ms02) （yl2022ms02）
江苏省中医药科技发展计划项目(MS2025117) （MS2025117）
