青岛大学学报（自然科学版）2026，Vol.39Issue(3)：9-14,6.DOI:10.3969/j.issn.1006-1037.2026.03.03
小克里斯滕森氏菌DSM 22607对动脉粥样硬化抑制作用
Inhibitory Effect of Christensenella Minuta DSM 22607 on Atherosclerosis
摘要
Abstract
To investigate the potential impact of Christensenella minuta(C.minuta)on atherosclerosis development,6-week-old male C57BL/6J mice and male ApoE-deficient mice(APOE-/-)were randomly assigned to 6 experimental groups,with 6 mice per group.The mice were modeled by feeding them regular feed and high-fat feed for 8 weeks.Subsequently,they were treated with PBS,C.minuta,atorvastatin(ator),and a mixture of C.minuta and atorvastatin by gavage.After an additional 8 weeks of treat-ment,aortic tissues and serum samples were collected for Oil Red O staining and inflam-matory factor analysis,respectively.Liver tissue RNA was extracted to assess the expres-sion levels of key inflammatory markers.The results showed that the atherosclerotic plaque area in APOE-/-mice administered with C.minuta by gavage was significantly smaller than that in the vehicle control group(P<0.000 1).The serum inflammatory factor IL-6 level in the C.minuta group was lower than that in the vehicle control group(P<0.001),and the serum TNF-α level was significantly reduced compared to the vehicle control group(P<0.000 1).The expression of IL-6 and TNF-α mRNA in the liver was consistent with that in the serum.It is confirmed that Christensenella minuta exerts an inhibitory effect on atherosclerosis progression,potentially mediated through suppression of systemic and hepatic inflammatory responses.关键词
小克里斯滕森氏菌DSM 22607/动脉粥样硬化/APOE基因敲除/炎症反应Key words
Christensenella minuta DSM 22607/atherosclerosis/APOE gene knockout/inflammatory response分类
医药卫生引用本文复制引用
曲薪惠,李培峰..小克里斯滕森氏菌DSM 22607对动脉粥样硬化抑制作用[J].青岛大学学报（自然科学版）,2026,39(3):9-14,6.
