器官移植2026，Vol.17Issue(5)：731-737,7.DOI:10.12464/j.issn.1674-7445.2026164
常温局部灌注支持下DCD供者劈离式肝移植的临床实践与前景展望
Clinical practice and prospect of split liver transplantation with DCD donors under normothermic regional perfusion support
摘要
Abstract
Due to the global shortage of organs,donation after circulatory death(DCD)has become an important source of liver grafts for liver transplantation.Nevertheless,its application is limited by warm ischemic injury and technical challenges associated with in-situ splitting,and safe protocols for split liver transplantation with DCD grafts remain lacking at present.Normothermic regional perfusion(NRP)rapidly re-establishes oxygenated abdominal blood supply after circulatory arrest,effectively alleviating warm ischemic injury and creating stable operative conditions for in-situ splitting of DCD liver grafts.To date,liver splitting performed under NRP has achieved certain advances in dynamic graft assessment,monitoring of metabolic recovery,and decision-making for graft splitting.Accordingly,this article reviews the technical adaptability and preliminary clinical outcomes of in-situ split liver transplantation with DCD grafts assisted by NRP,analyses the major obstacles to its popularization,and explores future research directions,so as to provide references for further clinical application of split liver transplantation.关键词
常温局部灌注/循环死亡器官捐献/心脏死亡器官捐献/劈离式肝移植/原位劈离/供肝质量评估Key words
Normothermic regional perfusion/Donation after circulatory death/Donation after cardiac death/Split liver transplantation/In-situ liver splitting/Donor liver quality assessment分类
医药卫生引用本文复制引用
贺健,高伟..常温局部灌注支持下DCD供者劈离式肝移植的临床实践与前景展望[J].器官移植,2026,17(5):731-737,7.基金项目
天津市医学重点学科建设项目(TJYXZDXK-3-006A) （TJYXZDXK-3-006A）
