器官移植2026，Vol.17Issue(5)：748-756,9.DOI:10.12464/j.issn.1674-7445.2026069
空间转录组学在肾移植病理研究中的应用进展
Application progress of spatial transcriptomics in the pathological research of kidney transplantation
摘要
Abstract
Kidney transplantation is the preferred treatment option for patients with end-stage renal disease.Although the short-term survival rate has significantly improved,factors such as rejection,ischemia-reperfusion injury(IRI),delayed graft function and renal fibrosis remain important factors affecting the long-term survival of transplanted kidneys.These pathological changes have clear spatial heterogeneity.Traditional transcriptome sequencing techniques lose cellular in situ spatial information and the communication information between cells,while spatial transcriptomics techniques can maintain the integrity of tissue structure and achieve high-resolution molecular analysis.They can precisely map the spatial distribution maps of gene expression and cell types,compensating for the limitations of traditional techniques.This review systematically summarizes the application progress of spatial transcriptomics techniques in kidney transplantation pathology research,focusing on the research findings in key pathological processes such as allogeneic rejection,xenotransplant rejection,IRI,delayed graft function and renal fibrosis.It also discusses the value of the techniques in analyzing tissue spatial heterogeneity,revealing cell interactions and dynamic evolution patterns,and their potential significance in early diagnosis,targeted therapy development and efficacy evaluation.It also analyzes the current challenges faced by the technologies,such as cost,resolution balance,data processing and limitations of sample spatial information.Finally,it looks forward to future directions such as multi-omics integration,artificial intelligence-driven analysis and dynamic longitudinal studies.关键词
空间转录组学/肾移植/病理改变/靶向治疗/终末期肾病/组织空间异质性/空间分布图谱/多组学整合Key words
Spatial transcriptomics/Kidney transplantation/Pathological change/Targeted therapy/End-stage renal disease/Tissue spatial heterogeneity/Spatial distribution map/Multi-omics integration分类
医药卫生引用本文复制引用
陈灿,文吉秋..空间转录组学在肾移植病理研究中的应用进展[J].器官移植,2026,17(5):748-756,9.基金项目
西藏自治区科技计划项目(重点研发计划)(XZ202301XY0003G) （重点研发计划）
