器官移植2026，Vol.17Issue(5)：757-764,8.DOI:10.12464/j.issn.1674-7445.2026135
可溶性C5b-9在肾移植术后移植物功能延迟恢复诊断中的应用价值
Application value of soluble C5b-9 in the diagnosis of delayed graft function after kidney transplantation
摘要
Abstract
Objective To explore the diagnostic value of soluble C5b-9(sC5b-9)for delayed graft function(DGF)following kidney transplantation.Methods Clinical data of 49 kidney transplant recipients who underwent sC5b-9 detection at the Second People's Hospital of Shanxi Province between January 2024 and December 2025 were retrospectively analyzed.Recipients were divided into the DGF group(n=25)and the non-DGF group(n=24)according to the occurrence of DGF.Baseline characteristics and serum sC5b-9 levels were compared between the two groups.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the diagnostic efficacy of sC5b-9 for DGF.A restricted cubic spline model was adopted to investigate the association between sC5b-9 and DGF.Results Among the 49 recipients,DGF occurred in 25 patients.Compared with the non-DGF group,the DGF group presented a higher proportion of male patients,a higher incidence of adverse transplant outcomes,and elevated final serum creatinine levels(all P＜0.05).Within 30 days after transplantation,sC5b-9 concentrations were significantly higher in the DGF group than those in the non-DGF group(P＜0.001).ROC analysis revealed that the area under the curve(AUC)of sC5b-9 for diagnosing DGF was 0.81,with a 95％confidence interval(CI)of 0.68-0.92,and the optimal cutoff value was 265.7 ng/mL.Recipients with elevated sC5b-9(≥265.7 ng/mL)had a significantly higher incidence of DGF than those with low sC5b-9 levels(＜265.7 ng/mL)(P＜0.001).Recipients with adverse outcomes exhibited significantly higher sC5b-9 levels than those without adverse outcomes(P＜0.001),and the AUC of sC5b-9 for identifying adverse outcomes was 0.82(95％CI 0.63-0.95).A significant nonlinear correlation was observed between sC5b-9 and final serum creatinine(P＜0.001).Conclusions Elevated sC5b-9 is correlated with the development of DGF after kidney transplantation and exhibits favorable diagnostic performance.It may serve as a potential biomarker for predicting early allograft dysfunction and adverse outcomes in kidney transplant recipients.关键词
肾移植/移植物功能延迟恢复/补体/sC5b-9/移植物原发性无功能/移植物丢失/依库珠单抗/血清肌酐Key words
Kidney transplantation/Delayed graft function/Complement/sC5b-9/Primary nonfunction graft/Graft loss/Eculizumab/Serum creatinine分类
医药卫生引用本文复制引用
尚丽红,王志华,张文艳,梁娇霞,王明君,李宁,石韶华,朱琳茹..可溶性C5b-9在肾移植术后移植物功能延迟恢复诊断中的应用价值[J].器官移植,2026,17(5):757-764,8.基金项目
山西省卫生健康委科研课题(2024139) （2024139）
