四川精神卫生2026，Vol.39Issue(4)：318-323,6.DOI:10.11886/scjsws20250723002
伴混合特征的双相障碍抑郁发作患者认知功能与事件相关电位P300的相关性及影响因素
Correlation between cognitive function and event-related potential P300 and its influencing factors in patients with depressive episodes of bipolar disorder with mixed features
摘要
Abstract
Background Patients with bipolar disorder exhibit persistent cognitive impairment across multiple domains,including executive function,memory,and attention.Furthermore,those with mixed features tend to have a poorer prognosis.Currently,research evidence regarding the characteristics of cognitive function and event-related potential P300,as well as their correlation,in patients with depressive episodes of bipolar disorder with mixed features remains limited.Objective To explore the correlation between cognitive function and event-related potential P300 in patients with depressive episodes of bipolar disorder with mixed features,analyze the influencing factors of cognitive function,so as to provide references for the improvement of cognitive function in this subtype of patients.Methods A total of 73 patients who met the diagnostic criteria for depressive episodes of bipolar disorder in the Diagnostic and Statistical Manual of Mental Disorders,fifth edition(DSM-5)were enrolled from the outpatient and inpatient departments of Tianjin Anding Hospital from November 2021 to April 2024.The Hamilton Depression Scale-17 item(HAMD-17)was used to assess the severity of depressive symptoms,and the Clinically Useful Depression Outcome Scale Supplemented with Questions for the DSM-5 Mixed Features Specifier(CUDOS-M)was used to evaluate whether patients presented with mixed features.Based on the CUDOS-M total scores,patients were divided into two groups:the mixed features group(n=34)and the non-mixed features group(n=39).The MATRICS Consensus Cognitive Battery(MCCB)was used to assess cognitive function,and auditory event-related potential P300 testing was performed.Spearman correlation analysis was used to examine the correlations between P300 indicators and MCCB scores.Multiple linear regression analysis was conducted to investigate the influencing factors of cognitive function.Results Patients with depressive episodes of bipolar disorder with mixed features had a longer total illness duration than those without mixed features,and the difference was statistically significant(t=2.030,P<0.05).Analysis of covariance showed that the MCCB scores for processing speed,attention/vigilance,and reasoning and problem solving were all lower in the mixed features group than those in the non-mixed features group(F=3.650,3.520,4.213,P<0.01).However,no significant difference was found between the two groups in P300 latency or amplitude(P>0.05).Correlation analysis revealed that the MCCB attention/vigilance score was negatively correlated with P300 latency in patients with depressive episodes of bipolar disorder with mixed features(rs=-0.576,P<0.01).Multiple linear regression analysis showed that,in the mixed features group,years of education positively predicted processing speed(β=0.378,P<0.05),while P300 latency(β=-0.699,P<0.01)and age(β=-0.424,P<0.01)negatively predicted attention/vigilance function.Conclusion Patients with depressive episodes of bipolar disorder with mixed features have a longer illness duration and more severe impairment in three cognitive domains:processing speed,attention/vigilance,and reasoning and problem solving.P300 latency may be an influencing factor of attention/vigilance function in patients with depressive episodes of bipolar disorder with mixed features.关键词
双相障碍/抑郁发作/混合特征/认知功能/事件相关电位Key words
Bipolar disorder/Depressive episode/Mixed features/Cognitive function/Event-related potentials分类
医药卫生引用本文复制引用
张健,何宇翔,吴彦清,刘芳,张燕,张勇..伴混合特征的双相障碍抑郁发作患者认知功能与事件相关电位P300的相关性及影响因素[J].四川精神卫生,2026,39(4):318-323,6.基金项目
天津市医学重点学科建设项目(项目名称:精神病学,项目编号:TJYXZDXK-3-015B) （项目名称:精神病学,项目编号:TJYXZDXK-3-015B）
天津市安定医院院级科研项目(项目名称:双相情感障碍伴混合特征的临床特点、认知功能水平、神经电生理特征及临床疗效的观察研究,项目编号:ADYKHT2021010) [Funded by Tianjin Key Medical Discipline Construction Project(number,TJYXZDXK-3-015B) （项目名称:双相情感障碍伴混合特征的临床特点、认知功能水平、神经电生理特征及临床疗效的观察研究,项目编号:ADYKHT2021010）
Hospital-level Scientific Research Project of Tianjin Anding Hospital(number,ADYKHT2021010)] （number,ADYKHT2021010）
