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肺肝样腺癌治疗模式及预后影响因素探索:一项多中心、回顾性研究

邹俊怡周进鲁畅兰海涛宋正波辇伟奇刘洋唐建宁王绎寇玲娜

肿瘤预防与治疗2026，Vol.39Issue(9)：745-752,8.

肿瘤预防与治疗2026，Vol.39Issue(9)：745-752,8.DOI:10.3969/j.issn.1674-0904.2026.09.003

肺肝样腺癌治疗模式及预后影响因素探索:一项多中心、回顾性研究

Exploring Treatment Patterns and Prognostic Factors in Hepatoid Adeno-carcinoma of the Lung:A Multicenter,Retrospective Study

邹俊怡 ¹周进 ²鲁畅 ³兰海涛 ⁴宋正波 ⁵辇伟奇 ⁶刘洋 ⁷唐建宁 ⁷王绎 ⁷寇玲娜⁷

作者信息

1. 610054 成都,电子科技大学医学院
2. 610054 成都,电子科技大学医学院||610041 成都,四川省肿瘤医院·研究所,四川省肿瘤临床医学研究中心,四川省癌症防治中心,电子科技大学附属肿瘤医院肿瘤内科
3. 519041 广州,广东省人民医院肺内科
4. 610072 成都,四川省医学科学院·四川省人民医院(电子科技大学附属医院)肿瘤中心
5. 310022 杭州,浙江省肿瘤医院 Ⅰ 期临床试验病房
6. 400013 重庆,重庆市中医院肿瘤科
7. 610041 成都,四川省肿瘤医院·研究所,四川省肿瘤临床医学研究中心,四川省癌症防治中心,电子科技大学附属肿瘤医院肿瘤内科
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摘要

Abstract

Objective:This study aimed to explore the optimal treatment patterns for hepatoid adenocarcinoma of the lung(HAL)and evaluate the predictive value of clinicopathological characteristics for survival.Methods:Patients with HAL who received first-line treatment between 2014～2024 across 18 hospitals in China were enrolled.Progression-free survival(PFS)was the primary endpoint.Survival differences between groups were compared using Log-rank tests,and multivariate Cox regression analysis identified independent prognostic factors.Results:Among 42 patients,the median age was 60.50 years,with males comprising 80.95%.Advanced-stage disease was diagnosed in 71.43%of patients.Median PFS was 6.33 months,with a 1-year PFS rate of 21.43%.Log-rank tests revealed that patients who received antiangiogenic therapy(HR=0.537,95%CI:0.276～1.046,P=0.046),combination treatment regimens(HR=0.500,95%CI:0.213～1.168,P=0.039),experienced adverse events(AEs)(HR=0.340,95%CI:0.171～0.675,P<0.001),achieved partial response(PR)as the best response(HR=0.263,95%CI:0.115～0.605,P<0.001),or exhibited post-treat-ment decline in serum alpha-fetoprotein(AFP)levels(HR=0.285,95%CI:0.108～0.751,P<0.001)had signifi-cantly prolonged PFS.Multivariate Cox analysis identified best response of PR during first-line therapy(HR=0.080,95%CI:0.008～0.814,P=0.033)and AEs occurrence(HR=0.091,95%CI:0.017～0.499,P=0.006)as in-dependent prognostic factors for PFS.Conclusion:HAL patients with treatment-related AEs or PR as best response showed better outcomes.Antiangiogenic therapy and combination treatment regimens may provide survival benefits,though prospec-tive studies are required for further validation.Dynamic changes in AFP levels serve as a crucial indicator for treatment re-sponse prediction and disease monitoring.

关键词

肺肝样腺癌/治疗模式/预后影响因素/生存情况/甲胎蛋白

Key words

Hepatoid adenocarcinoma of the lung/Treatment patterns/Prognostic factors/Survival outcomes/Alpha-feto-protein

分类

医药卫生

引用本文复制引用

邹俊怡,周进,鲁畅,兰海涛,宋正波,辇伟奇,刘洋,唐建宁,王绎,寇玲娜..肺肝样腺癌治疗模式及预后影响因素探索:一项多中心、回顾性研究[J].肿瘤预防与治疗,2026,39(9):745-752,8.

基金项目

四川省科技计划项目(编号:2025YFHZ0248) （编号:2025YFHZ0248）

2022CSCO重点项目(编号:Y-2021AST/zd-0119) This study was supported by grants from Science and Technology Department of Sichuan Province(No.2025YFHZ0248)and Chinese Society of Clinical Oncology(No.Y-2021AST/zd-0119). （编号:Y-2021AST/zd-0119）

肿瘤预防与治疗

ISSN：1674-0904

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